Results 51 to 60 of about 329,604 (267)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Бонитетна оценка на Техногенни почви. I. Пригодност за отглеждане на есенни култури

Почвознание, агрохимия и екология, 2010
Reclamation of Technosols allowing their agricultural use was held in the region of mines “Maritsa-Iztok”, Bulgaria. This paper deals with the suitability of Technosols for growing autumn crops wheat, barley and rye.
ВЕНЕРА ЦОЛОВА, МАРИАНА ХРИСТОВА, ВЕНЕТА КРЪСТЕВА, МАРТИН БАНОВ   +3 more
doaj  

Habitat Integrity Challenges for the Chinese Alligator Amid Land Occupation by Human: Pathways for Protection

Ecology and Evolution
Effective conservation of endangered species necessitates not only the preservation of core habitats but also the enhancement of landscape connectivity. As a critically endangered Crocodylia, the Chinese alligator (Alligator sinensis) strongly relies on ...
Ke Sun, Meng Li, Ziyi Wang, Siqing Sun, Jiayue Yang, Xiaobing Wu, Tao Pan   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

محطات ضخ الوقود في ريف مركز المحلة الكبرى دراسة جغرافية تحليلية باستخدام نظم المعلومات الجغرافية [PDF]

Mağallaẗ Kulliyyaẗ Al-Adāb Bi-Qinā
تهدف الدراسة إلى توضيح مدي توافق توزيع محطات ضخ الوقود في ريف مركز المحلة الكبرى مع متطلبات الخدمة ، وحجم التباين في السعة التخزينية للوقود بأنواعه، وبيان المناطق ذات الكفاءة العالية، وأهم مناطق الملاءمة لإقامة محطات جديدة، إضافة إلى التعرف على المشكلات .
إيمان محمد فتحي عبداللا, هبه عزاز عبدالغني الطويل, ياسمين ابراهيم محمد نوح   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of readability and suitability of occupational safety and health posters [PDF]

Payesh
Objective(s): Printed educational materials have long shown their usefulness as a cost-effective and effective media for health communication. These resources are effective when they are understandable to their audience.
Zeinab Alimohammadi, Amin Mirzaei, Shiva Soury, Mohammadmehdi Naghizadeh, Zeinab Ghazanfari   +4 more
doaj  

Study of Basaltic Soils Along the Toposequence of Aya River in Ogoja, Cross River State, Nigeria [PDF]

Bulgarian Journal of Soil Science
An investigation was carried out on selected properties of basaltic soils along the toposequence of Aya river in Ogoja Cross river state. The soils are deep and occur on a gentle and undulating landscape with a gradient of
P.E. Imadojemu, S.N. Obasi
doaj   +1 more source