Results 81 to 90 of about 1,356,975 (362)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Suitability [PDF]

open access: yes
The suitability of grazing, burning, mowing and cutting as tools for succession control in peatland was assessed and expressed on a scale from 0 - 1. All management tools are suitable, but their effects are conditional.
Bokdam, J., Braeckel, A., van
core   +1 more source

Zeolitized tuffs in pedotechnique for quarry restoration: evaluation of phytonutritional efficiency in ^AUP model horizons [PDF]

open access: yes, 2012
A study was started aiming at assessing the suitability of zeolitized tuff as optimal mineral Human Transported Materials (HTMs) in pedotechnologies for quarry ...
Buondonno, Andrea   +8 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Evaluation of the Suitability of a Composite Liner System for Designing a Landfill Bioreactor on Confined Bedrock at Sammanthurai in Sri Lanka

open access: yesTropical Agricultural Research, 2011
The development of a low cost and environmentally friendly liner system is essential for countries like Sri Lanka because the high-density polyethylene liner is of high cost and much more prone to toxic conditions and failures.
R Thivyatharsan   +4 more
doaj   +1 more source

A formal verification framework and associated tools for enterprise modeling : application to UEML [PDF]

open access: yes, 2005
The aim of this paper is to propose and apply a verification and validation approach to Enterprise Modeling that enables the user to improve the relevance and correctness, the suitability and coherence of a model by using properties specification and ...
Allen   +34 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Evaluation of readability and suitability of occupational safety and health posters [PDF]

open access: yesPayesh
Objective(s): Printed educational materials have long shown their usefulness as a cost-effective and effective media for health communication. These resources are effective when they are understandable to their audience.
Zeinab Alimohammadi   +4 more
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

TAHLÎL MULÂIMAH BUNÛD IKHTIBÂR AL-LUGHAH AL-‘ARABIYYAH AL-NIHÂÎ AL-WATHANÎ LI MANHAJ MUSTAWÂ AL-WAHDAH AL-TA’LÎMIYYAH (KTSP) WA TASHNÎF BLOOM AL-MU’ADDAL

open access: yesArabiyat, 2020
This study aims to describe the suitability of Arabic language question item with educational unit level curriculum (KTSP) and Bloom’s taxonomy at the Final National Standard Madrasah (UAMBN) at Senior High School.
Uril Bahruddin, Muhammad Qodri
doaj   +1 more source

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