Results 131 to 140 of about 2,015,869 (349)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Le volcanisme (suite)

Le Globe. Revue genevoise de géographie, 1908
Brun Albert. Le volcanisme (suite). In: Le Globe. Revue genevoise de géographie, tome 47, 1908. pp. 39-42.
openaire   +8 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

SUITE BRITEL [PDF]

, 2018
La información, ese bien que influencia tiene en el mundo moderno por su capacidad de provocar cambios en quién la recibe, alcanza su máximo exponente cuando se produce su difusión. Uno de los canales más importantes de difusión y transmisión de la información es la TV, que utiliza diferentes medios de transmisión (telecomunicaciones) para hacer llegar
openaire   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Notes floristiques (Suite) [PDF]

, 1911
M. G. Rouy
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetes

Communications Medicine
Background Natural HbA1c levels in GCK Maturity-onset diabetes of the young (GCK-MODY) patients often sit above the diagnostic threshold for type 2 diabetes (T2D).
Kelly M. Schiabor Barrett, Natalie Telis, Lisa M. McEwen, Evanette K. Burrows, Basil Khuder, Daniel P. Judge, Pamala A. Pawloski, Joseph J. Grzymski, Nicole L. Washington, Alexandre Bolze, Elizabeth T. Cirulli   +10 more
doaj   +1 more source

The Moon’s Early Magmatic Activities: From the Perspective of Lunar Alkali-Suite and Mg-Suite Samples

Space: Science & Technology
This review places emphasis on ancient lunar nonmare igneous samples alkali-suite and Mg-suite. The material on mineralogy and petrology of the Mg-suite presented here draws from “Lunar samples” by Papike et al.
Wei Du, Jing Yang
doaj   +1 more source

Chaleur développée dans une masse d'oxyde de thorium par suite de sa radioactivité [PDF]

, 1908
G. B. Pegram, H.J. Webb
openalex   +1 more source