Trimethoprim/sulfamethoxazole-triggered drug-induced hypersensitivity syndrome in an HLA B*13:01-positive kidney transplant recipient: a case report with implications for HLA-severe cutaneous adverse reaction associations in transplant care. [PDF]
CEN Case RepTomizawa M +9 more
europepmc +1 more source
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Pan‐drug resistant Klebsiella pneumoniae is a major therapeutic challenge, particularly when standard last‐line agents are unavailable or contraindicated. We report a 45‐year‐old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad‐spectrum antibiotics, repeated debridement, and two sequential amputations ...
Ali Akbar Heydari +2 more
wiley +1 more source
Antimicrobial Drug Prophylaxis for Recurrent Ocular Toxoplasmosis. [PDF]
PathogensKeshavarz T, Furtado JM, Smith JR.
europepmc +1 more source
Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond
Comprehensive Physiology, Volume 16, Issue 4, August 2026.Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong +3 more
wiley +1 more source
Co-Resistance Structure and Multidrug Resistance-Associated Antimicrobials in <i>Escherichia coli</i> from Healthy Pigs in Japan: A Computational Analysis of JVARM Data, 2012-2023. [PDF]
Antibiotics (Basel)Hosoi Y +5 more
europepmc +1 more source
A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation
Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 324-333, August 2026.The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix +4 more
wiley +1 more source
Different Strains of Microalgae in a Microbial Consortium Remove Antibiotics from Urban Wastewater in Batch and Continuous Treatment Systems. [PDF]
ACS OmegaVargas SR +5 more
europepmc +1 more source
Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans
Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 510-519, August 2026.Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley +1 more source
Adverse events of trimetroprim-sulphonamide treatment of cats and dogs: a systematic review. [PDF]
Vet Res CommunEkstrand C +3 more
europepmc +1 more source
Effects of Timing of Microbial Exposure on Microbiome Assembly and Amphibian Immune Development
Ecology and Evolution, Volume 16, Issue 8, August 2026.We used a novel amphibian gnotobiotic system to investigate how disruptions to the microbiome during critical developmental periods influence microbial assembly and the development of immunity. We found that antimicrobial treatments of embryos and subsequent introduction to microbes at different developmental stages altered microbiome assembly ...
Abigail J. Miller +5 more
wiley +1 more source