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Expert Opinion on Therapeutic Patents, 2003
AbstractSteroid sulfatase (STS) regulates the local production of estrogens and androgens from systemic precursors in several tissues. The enzyme catalyzes the hydrolysis of the sulfate esters of 3‐hydroxy steroids, which are inactive transport or precursor forms of the active 3‐hydroxy steroids.
Peter, Nussbaumer, Andreas, Billich
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AbstractSteroid sulfatase (STS) regulates the local production of estrogens and androgens from systemic precursors in several tissues. The enzyme catalyzes the hydrolysis of the sulfate esters of 3‐hydroxy steroids, which are inactive transport or precursor forms of the active 3‐hydroxy steroids.
Peter, Nussbaumer, Andreas, Billich
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Rapid degradation of steroid sulfatase in multiple sulfatase deficiency
Biochemical and Biophysical Research Communications, 1986Pulse labeling followed by SDS-PAGE electrophoresis of immunoprecipitated [35S]methionine-labeled steroid sulfatase (STS) gave a single band of molecular weight 65,000 daltons. After a chase period of 18 hours the material appeared as molecular weight approximately 64,000.
A L, Horwitz +3 more
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Annual Review of Genomics and Human Genetics, 2005
▪ Abstract Sulfatases are a highly conserved family of proteins that cleave sulfate esters from a wide range of substrates. The importance of sulfatases in human metabolism is underscored by the presence of at least eight human monogenic diseases caused by the deficiency of individual sulfatases. Sulfatase activity requires a unique posttranslational
Andrea Ballabio
exaly +4 more sources
▪ Abstract Sulfatases are a highly conserved family of proteins that cleave sulfate esters from a wide range of substrates. The importance of sulfatases in human metabolism is underscored by the presence of at least eight human monogenic diseases caused by the deficiency of individual sulfatases. Sulfatase activity requires a unique posttranslational
Andrea Ballabio
exaly +4 more sources
Current Opinion in Genetics & Development, 1997
During the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a genomic approach ...
PARENTI, GIANCARLO +2 more
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During the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a genomic approach ...
PARENTI, GIANCARLO +2 more
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Marine Genomics, 2013
The whole genome sequence of Rhodopirellula baltica SH1(T), published nearly 10years ago, already revealed a high amount of sulfatase genes. So far, little is known about the diversity and potential functions mediated by sulfatases in Planctomycetes. We combined in vivo and in silico techniques to gain insights into the ecophysiology of planktomycetal ...
Carl-Eric Wegner +2 more
exaly +4 more sources
The whole genome sequence of Rhodopirellula baltica SH1(T), published nearly 10years ago, already revealed a high amount of sulfatase genes. So far, little is known about the diversity and potential functions mediated by sulfatases in Planctomycetes. We combined in vivo and in silico techniques to gain insights into the ecophysiology of planktomycetal ...
Carl-Eric Wegner +2 more
exaly +4 more sources
Lysosomal sulfatases: a growing family
Biochemical Journal, 2020Sulfatases constitute a family of enzymes that specifically act in the hydrolytic degradation of sulfated metabolites by removing sulfate monoesters from various substrates, particularly glycolipids and glycosaminoglycans. A common essential feature of all known eukaryotic sulfatases is the posttranslational modification of a critical cysteine residue ...
Lübke, Torben, Damme, Markus
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Neurology, 1988
Multiple sulfatase deficiency is an inherited disorder characterized by a deficiency of several sulfatases and the accumulation of sulfatides, glycosaminoglycans, sphingolipids, and steroid sulfates in tissues and body fluids. The clinical manifestations represent the summation of two diseases: late infantile metachromatic leukodystrophy and ...
B W, Soong +4 more
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Multiple sulfatase deficiency is an inherited disorder characterized by a deficiency of several sulfatases and the accumulation of sulfatides, glycosaminoglycans, sphingolipids, and steroid sulfates in tissues and body fluids. The clinical manifestations represent the summation of two diseases: late infantile metachromatic leukodystrophy and ...
B W, Soong +4 more
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Journal of Steroid Biochemistry, 1974
The conversion of 5-en-3β-ol steroid sulfates to active hormones has been extensively studied. A preliminary desulfation of the precursors is required to allow their structure 5-ene-3β-ol to be transformed to the con-figuration 4-ene-3-keto present in active hormones.
O.V. DOMÍNGUEZ +3 more
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The conversion of 5-en-3β-ol steroid sulfates to active hormones has been extensively studied. A preliminary desulfation of the precursors is required to allow their structure 5-ene-3β-ol to be transformed to the con-figuration 4-ene-3-keto present in active hormones.
O.V. DOMÍNGUEZ +3 more
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Developmental regulation of choline sulfatase and aryl sulfatase in Neurospora crassa
Archives of Biochemistry and Biophysics, 1974Abstract Regulation of the synthesis of several enzymes of sulfur metabolism in Neurospora is a function of both metabolic regulation and the genetic control exerted by the cys -3 and scon regulatory genes. Additional control mechanisms appear to regulate the synthesis of choline sulfatase and aryl sulfatase in different developmental stages of ...
W G, McGuire, G A, Marzluf
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