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The Multiple Sulfatase Deficiency Gene Encodes an Essential and Limiting Factor for the Activity of Sulfatases [PDF]

Cell, 2003
In multiple sulfatase deficiency (MSD), a human inherited disorder, the activities of all sulfatases are impaired due to a defect in posttranslational modification. Here we report the identification, by functional complementation using microcell-mediated chromosome transfer, of a gene that is mutated in MSD and is able to rescue the enzymatic ...
Maria Pia Cosma, Stefano Pepe, Robert F Newbold   +2 more
exaly   +7 more sources

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Steroid sulfatase, arylsulfatases A and B, galactose-6-sulfatase, and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfatase activity

The Journal of Steroid Biochemistry and Molecular Biology, 2007
Sulfatase enzymes have important roles in metabolism of steroid hormones and of glycosaminoglycans (GAGs). The activity of five sulfatase enzymes, including steroid sulfatase (STS; arylsulfatase C), arylsulfatase A (ASA; cerebroside sulfatase), arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase), galactose-6-sulfatase (GALNS), and iduronate-2 ...
Sumit, Bhattacharyya, Joanne K, Tobacman
openaire   +2 more sources

Estrogen Sulfatase

2005
Estrogen sulfatase is a microsomal enzyme and is ubiquitously distributed in several mammalian tissues, among which the liver, placenta, and endocrine tissues exhibit relatively high activity. Because the major circulating precursors of estrogen are estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, estrogen sulfatase plays an important role not ...
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Properties of sulfatases in cultured skin fibroblasts of multiple sulfatase deficient patients

Clinical Genetics, 1981
Various sulfatase activities were assayed in cultured skin fibroblasts from patients with multiple sulfatase deficiency (MSD). MSD cell lines displayed deficiencies of arylsulfatase A and iduronate sulfatase, but activities of arylsulfatase B, N‐acetylgalactosamine 6‐sulfate sulfatase and N‐acetylglucosamine 6‐sulfate sulfatase were within normal ...
T, Yutaka, S, Okada, T, Kato, K, Inui, H, Yabuuchi   +4 more
openaire   +2 more sources

Synthesis and sulfatase inhibitory activities of non-steroidal estrone sulfatase inhibitors

The Journal of Steroid Biochemistry and Molecular Biology, 1996
About one-third of breast cancers are classified as estrogen-dependent breast cancers. In the past 10 years, numerous reports have suggested the importance of estrone sulfate and estrone sulfatase in regulating the supply of estrogens to these cancers. Estrone sulfatase inhibitors may thus prove to be useful for the treatment of these diseases. Several
P K, Li, S, Milano, L, Kluth, M E, Rhodes   +3 more
openaire   +2 more sources

Synthesis and Stability of Steroid Sulfatase in Fibroblasts from Multiple Sulfatase Deficiency

Biological Chemistry Hoppe-Seyler, 1988
Multiple sulfatase deficiency is a lysosomal storage disorder, which can be divided into group I with severe and group II with moderate deficiencies in sulfatases. Antibodies raised against steroid sulfatase purified from human placenta were used to follow the biosynthesis and stability of this enzyme in multiple sulfatase-deficiency fibroblasts ...
J T, Conary, A, Hasilik, K, von Figura
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Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase

Biochemical and Biophysical Research Communications, 1988
Glucosamine-6-sulfatase is a lysosomal enzyme which degrades glycosaminoglycans and is deficient in mucopolysaccharidosis type IIID. Human liver contains two major active forms of glucosamine-6-sulfatase, form A which has a single 78 kDa polypeptide and form B which has two polypeptides of 48 kDa and 32 kDa.
D A, Robertson, C, Freeman, P V, Nelson, C P, Morris, J J, Hopwood   +4 more
openaire   +2 more sources

Multiple Sulfatase Deficiency and the Nature of the Sulfatase Family

2000
eighth ...
HOPWOOD J. J, BALLABIO, ANDREA
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The Sulfatase of Ox Liver. IX. The Polymerization of Sulfatase A^*

Biochemistry, 1965
L W, NICHOL, A B, ROY
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The common identity of 4-sulfatase, nitrocatechnol sulfatase (arylsulfatase), and chondroitin 4-sulfatase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1980
Masahiro Tsuji, Yasuo Nakanishi, Hiroko Habuchi, Kazuhiko Ishihara, Sakaru Suzuki   +4 more
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