Results 131 to 140 of about 114,841 (367)

Perfluoroalkanesulfonamide Organocatalysts for Asymmetric Conjugate Additions of Branched Aldehydes to Vinyl Sulfones

Molecules, 2013
Asymmetric conjugate additions of branched aldehydes to vinyl sulfones promoted by sulfonamide organocatalyst 6 or 7 have been developed, allowing facile synthesis of the corresponding adducts with all-carbon quaternary stereocenters in excellent yields ...
Kosuke Nakashima, Miho Murahashi, Hiroki Yuasa, Mariko Ina, Norihiro Tada, Akichika Itoh, Shin-ichi Hirashima, Yuji Koseki, Tsuyoshi Miura   +8 more
doaj   +1 more source

Biologic Changes in Sulfonamide-resistant Mycobacterium ranae [PDF]

, 1946
Dirán Yegian, Vera Budd, Gardner Middlebrook   +2 more
openalex   +1 more source

Designing Cyclic Nitrogen‐Bridged Sulfonamides with Anti‐Cancer Activity

ChemMedChem, EarlyView.
Nitrogen bridgehead compounds, especially cyclic sulfonamides, are an abundant motif in bioactive compounds. simple methods for the synthesis of nitrogen bridgehead sulfonamides is developed and their activity against cancer cell lines is explored. The N‐bridgehead heterocyclic structure is an abundant motif in a multitude of natural products.
Benedikt W. Grau, Arpit Dheeraj, Irimpan I. Mathews, Dhanir Tailor, Sanjay V. Malhotra   +4 more
wiley   +1 more source

Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
We discovered novel and selective sulfonamides/amides acting as inhibitors of the α-carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae (VchCA).
Daniela De Vita, Andrea Angeli, Fabiana Pandolfi, Martina Bortolami, Roberta Costi, Roberto Di Santo, Elisabetta Suffredini, Mariangela Ceruso, Sonia Del Prete, Clemente Capasso, Luigi Scipione, Claudiu T. Supuran   +11 more
doaj   +1 more source

Crystal structure of methyl 1-methyl-3,5-diphenyl-7-tosyl-3,6,7,11b-tetrahydropyrazolo[4′,3′:5,6]pyrano[3,4-c]quinoline-5a(5H)-carboxylate

Acta Crystallographica Section E, 2014
In the title compound, C35H31N3O5S, the piperidine ring adopts an envelope conformation, with the methine C atom as the flap, and the pyran ring adopts a sofa conformation.
Eswar Kumar Nadendla, G. Jagadeesan, D. Kannan, Mannickam Bakthadoss, K. Gunasekaran   +4 more
doaj   +1 more source

Folinsäure-Synthese und antibakterielle Wirkung der Sulfonamide [PDF]

, 1947
Rudolf Tschesche, Klaus Soehring, Käthi Härder   +2 more
openalex   +1 more source

Antimicrobial sulfonamide drugs

, 2017
Sulfonamides are the first successfully synthesized antimicrobial drugs. The mechanism of sulfonamides antimicrobial action involves competitive inhibition of folic acid synthesis which prevents the growth and reproduction of microorganisms.
Ana Tačić, V. Nikolić, L. Nikolić, I. Savić   +3 more
semanticscholar   +1 more source

Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

ChemMedChem, EarlyView.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez‐Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania Ciaglia   +17 more
wiley   +1 more source

Inhibition of the clathrin terminal domain – amphiphysin protein‐protein interaction. Probing the Pitstop® 2 aromatic moiety.

ChemMedChem, Accepted Article.
Pitstop 2, (Z)‐N‐(5‐(4‐bromenzylidene)‐4‐oxo‐4,5‐dihydrothiazol‐2‐yl)naphthalene‐1‐sulfonamide (1), inhibits the clathrin terminal domain‐ amphiphysin interaction (NTD‐PPI) and has been widely used to investigate endocytosis. In this work we report on the synthesis of 56 novel Pitstop 2 analogues via four discrete focused libraries.
Kate Prichard, Mark J Robertson, Ngoc Chau, Jing Xue, Martin Neuenschwander, Uwe Fink, Andre Horatscheck, Marc Nazare, Phillip J Robinson, Volker Haucke, Adam McCluskey   +10 more
wiley   +1 more source

In VitroStudies Concerning the Action of Penicillin on the Viridans Streptococci, Including Observations on the So-called Synergistic Effect of Sulfonamide Drugs [PDF]

, 1946
Benedict F. Massell, Mary Meyeserian, T. Duckett Jones   +2 more
openalex   +1 more source