Results 221 to 230 of about 46,498 (299)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Synthesis of unprotected thienyl sulfonamides and their activities against carbapenem-resistant <i>Klebsiella pneumoniae</i>, docking studies and ADMET analysis. [PDF]

RSC Adv
Bilal M, Noreen M, Usman Qamar M, Siddique F, Rasool N, Imran M.   +5 more
europepmc   +1 more source

A Case of Disseminated Nocardiosis due to Nocardia otitidiscaviarum With Pulmonary Infection and a Thyroid Abscess

Respirology Case Reports, Volume 14, Issue 7, July 2026.
Nocardia otitidiscaviarum is a rare pathogen worldwide compared with other Nocardia species. Although Nocardia infections occur mainly in immunocompromised individuals and typically involve lungs and skin, cases in immunocompetent hosts have also been reported in recent years.
Seigo Miyoshi, Miyuki Tanabe, Tetsuya Yamamoto, Mayuko Semba, Chika Sato, Akira Watanabe, Sohei Kitazawa, Ryoji Ito   +7 more
wiley   +1 more source

Efficacy of sulfonamides targeting malic enzyme in an animal model of Chagas disease. [PDF]

Front Pharmacol
Dos Santos TCF, da Silva RB, de Sousa IL, Naciuk FF, Marchese L, Eufrásio AG, Lobo-Rojas AE, Giampauli RM, de Souza VB, Schenka AA, Bruder M, Rocco SA, Cordeiro AT.   +12 more
europepmc   +1 more source

Seasonal Prevalence, Molecular Identification and Therapeutic Management of Enterotoxemia Caused by Clostridium perfringens Type D in Goats of Peshawar and Charsadda Districts, Pakistan

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Seasonal enterotoxaemia outbreaks in goats from the Peshawar and Charsadda districts were investigated through large‐scale faecal sampling, bacterial isolation, PCR‐based molecular confirmation of the etx gene, antimicrobial susceptibility testing and clinico‐therapeutic trials. The study demonstrates higher disease prevalence during spring and winter,
Inam Ul Haq, Haq Aman Ullah, Muqadar Shah, Rifat Ullah Khan, Shabana Naz, Antonella Perillo, Sohail Ahmad, Ibrahim A. Alhidary   +7 more
wiley   +1 more source

<i>N</i>-Ethyl Perfluorooctane Sulfonamide (<i>N</i>-EtFOSA) Exposure Alters Microbiome Composition and Causes Microbiome-Dependent Behavior Effects in Larval Zebrafish. [PDF]

Environ Sci Technol
Gutsfeld S, Wray C, Schweiger N, Röhrig A, Paschke H, Fu Q, Kasmanas JC, Abdulkadir N, Kader S, Rocha U, Ebert A, Tal T.   +11 more
europepmc   +1 more source

Evaluation of the Utilization Pattern of Veterinary Drugs in Selected Veterinary Clinics of Mekelle City, Tigray, Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Veterinary drug utilization patterns were assessed in three veterinary clinics in Mekelle City, Ethiopia. Antimicrobials, particularly oxytetracycline, constitute the majority of prescriptions, followed by anthelmintics. Drug prescribing frequently relies on tentative diagnosis rather than evidence‐based diagnostic procedures.
Helen Hagos, Mebrahtu Weldegebriel, Hagazi Fantay, Haftom Yirga Tsegay   +3 more
wiley   +1 more source

Whole Genome Sequencing Reveals High Prevalence of Antimicrobial Resistance Genes in <i>Salmonella</i> Isolates From Diarrheal Patients in Jinan, China. [PDF]

Can J Infect Dis Med Microbiol
Ma C, Li N, Wang L, Li K, Liu M, Zhou J, Liu H.   +6 more
europepmc   +1 more source

Investigating the resistome, taxonomic composition, and mobilome of bacterial communities in hospital wastewaters of Metro Manila using a shotgun metagenomics approach. [PDF]

Microbiol Spectr
Santos JCE, Go DJL, Unciano RD, Yu PK, Lao AR, Enriquez MLD, Espiritu LM, Shrestha AMS.   +7 more
europepmc   +1 more source