Results 41 to 50 of about 39,692 (244)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Investigation of General Power Sum-Connectivity Index for Some Classes of Extremal Graphs

Complexity, 2021
In this work, we introduce a new topological index called a general power sum-connectivity index and we discuss this graph invariant for some classes of extremal graphs.
Rui Cheng, Gohar Ali, Gul Rahmat, Muhammad Yasin Khan, Andrea Semanicova-Fenovcikova, Jia-Bao Liu   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

On Some Properties of Fuzzy Topological Indices of Honeycomb Graph

Journal of Mathematics
The primary contribution of this paper is the characterization of a novel graph structure, the fuzzy honeycomb network, through the lens of fuzzy molecular descriptors.
Sana Shafqat, Naveed Yaqoob, Aliya Javed
doaj   +1 more source

Eccentric connectivity index and eccentric distance sum of some graph operations [PDF]

Transactions on Combinatorics, 2013
Let $G=(V,E)$ be a connected graph. The eccentric connectivity index of $G$, $xi^{c}(G)$, is defined as $xi^{c}(G)=sum_{vin V(G)}deg(v)ec(v)$, where $deg(v)$ is the degree of a vertex $v$ and $ec(v)$ is its eccentricity. The eccentric distance sum of $G$
Buzohragul Eskender, Elkin Vumar
doaj  

Certain topological indices and polynomials for the semitotal-point graph and line graph of semitotal-point graph for Dutch windmill graph

Indonesian Journal of Combinatorics, 2020
Dutch windmill graph [1, 2] and denoted by Dnm. Order and size of Dutch windmill graph are (n−1)m+1 and mn respectively. In this paper, we computed certain topological indices and polynomials i.e.
Salma Kanwal, Mariam Imtiaz, Ayesha Manzoor, Nazeeran Idrees, Ammara Afzal   +4 more
doaj   +1 more source

Some degree-based topological indices of caboxy-terminated dendritic macromolecule

Main Group Metal Chemistry, 2021
In the modern era of the chemical science, the chemical graph theory has contributed significantly to exploring the properties of the chemical compounds.
Rao Yongsheng, Kanwal Ammarah, Abbas Riffat, Noureen Saima, Fahad Asfand, Qureshi Muhammad Imran   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source