Results 151 to 160 of about 39,522 (208)

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Advanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu   +14 more
wiley   +1 more source

Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan, Beibei Xu, Jenna McCormack, XuHai Huang, Jingzhe Ma, Thomas Marshall, Yacong Sun, Hardeep Singh, Alyssa Fanelli, Gauri Kulkarni, Ji Hye Seo, Paige Gilbride, Bing Wei, Bo Wang, Yanyan Liu, Fei Ma, Lin Zhou, Shuyang Wang, Xiaohua Qian, Zhiyong Xie, Polina Golland, Longlong Si, Yu Shrike Zhang, Xin Xie, Haiqing Bai   +24 more
wiley   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Membrane‐Mediated Force Transduction Drives Stick‐Slip Motion of Lipid Vesicles

Advanced Science, EarlyView.
A rotating magnetic field actuates a ferromagnetic particle inside a lipid vesicle, generating internal flows that induce stick‐slip propulsion near a surface. Membrane properties—elasticity, excess area, and phase behavior—modulate this motion by shaping stress dissipation and force transduction.
Paula Magrinya, Arin Escobar Ortiz, Juan L. Aragones, Laura R. Arriaga   +3 more
wiley   +1 more source

Two Distinct Phonon Wave Effects Control Thermal Transport across the Coherent–Incoherent Regime in Superlattices

Advanced Science, EarlyView.
Thermal transport in smooth‐interface superlattices is studied using the phonon Wigner transport equation, which captures both particle‐like and wave‐like contributions. A minimum in cross‐plane thermal conductivity emerges with increasing period thickness, signaling a crossover from coherent to incoherent phonon transport.
Jin Yang, Jingyi Zhu, Alan J. H. McGaughey, Wee‐Liat Ong   +3 more
wiley   +1 more source

Spectral Decomposition of Chemical Semantics for Activity Cliffs‐Aware Molecular Property Prediction

Advanced Science, EarlyView.
PrismNet mimics chemical intuition by functioning as a computational prism, refracting molecular graphs into complementary semantic views and spectral frequencies. This dual‐decomposition strategy effectively captures both global topologies and subtle “activity cliff” perturbations.
Chaoyang Xie, Junhu Xu, Guangyi Huang, Shihang Wang, Mutian He, Xinyu Dong, Huiyang Hong, Xiaojun Yao, Qi Wang, Yuquan Li   +9 more
wiley   +1 more source

A Scalable Method for Cavity‐Enhanced Solid‐State Quantum Sensors

Advanced Science, EarlyView.
Photoluminescent color centres in diamond and hexagon boron nitride are powerful nanoscale solid‐state quantum sensors. Methods for integrating them into macroscopic structures that improve their sensitivity are highly sought after. This study demonstrates a low‐cost and scalable method for the fabrication of quantum sensor‐doped thin‐film cavities ...
Daniel J. Tibben, Roy Styles, David A. Broadway, Jean‐Philippe Tetienne, Daniel E. Gómez, Philipp Reineck   +5 more
wiley   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries

Advanced Science, EarlyView.
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang, Wenkai Wang, Zhenling Peng, Jianyi Yang   +3 more
wiley   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source