Results 131 to 140 of about 3,753,733 (329)

Cross-Trait Prediction Accuracy of Summary Statistics in Genome-Wide Association Studies

, 2022
Bingxin Zhao, Fei Zou, Hongtu Zhu
openalex   +2 more sources

A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics [PDF]

, 2021
Haojie Lu, Jiahao Qiao, Zhonghe Shao, Ting Wang, Shuiping Huang, Ping Zeng   +5 more
openalex   +1 more source

Summary statistics and discrepancy measures for approximate Bayesian computation via surrogate posteriors

Statistics and computing, 2022
F. Forbes, H. Nguyen, TrungTin Nguyen, Julyan Arbel   +3 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Commentary on Unnecessary reliance on multilevel modelling to analyse nested data in neuroscience: When a traditional summary-statistics approach suffices

, 2022
Paul Alexander Bloom, Monica Kim Ngan Thieu, Niall Bolger   +2 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A flexible summary statistics-based colocalization method with application to the mucin cystic fibrosis lung disease modifier locus [PDF]

, 2022
Fan Wang, Naim Panjwani, Cheng Wang, Lei Sun, Lisa J. Strug   +4 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Enabling Trade-offs in Privacy and Utility in Genomic Data Beacons and Summary Statistics [PDF]

, 2023
Rajagopal Venkatesaramani, Zhiyu Wan, Bradley Malin, Yevgeniy Vorobeychik   +3 more
openalex   +1 more source