Results 151 to 160 of about 3,753,733 (329)

Summary Statistics for Fun Dough Data Acquired at LLNL

open access: green, 2010
J.S. Kallman   +8 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Summary statistics for the InsPIRE consortium (pancreatic islets eQTLs)

open access: green, 2019
Ana Viñuela   +34 more
openalex   +1 more source

Anthropometric study of U.S. truck drivers: methods, summary statistics, and multivariate accommodation models. [PDF]

open access: gold, 2015
Jinhua Guan   +58 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Quantification of Small‐Scale Spatial Patterns in Alpine–Treeline Ecotones

open access: yesEcology and Evolution
Alpine treeline ecotones, when viewed up close, display considerable variation in spatial patterns, which have been associated with different responses to climate change. Two important dimensions of treeline‐ecotone spatial patterns are the abruptness of
Lukas Flinspach   +5 more
doaj   +1 more source

Full summary statistics of mixQTL for GTEx v8 Brain_Nucleus_accumbens_basal_ganglia

open access: green, 2020
Yanyu Liang   +4 more
openalex   +2 more sources

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