Results 171 to 180 of about 3,292,350 (321)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Collaborative Inference for Accelerated Failure Time Model Using Clinical Center-Level Summary Statistics. [PDF]

Stat Med
Hu M, Shi X, Gong Z, Song PX.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Logica: A likelihood framework for cross-ancestry local genetic correlation estimation using summary statistics. [PDF]

Am J Hum Genet
Gao B, Li Z, Zhou X.
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Summary-2 of RNA-seq and mapping statistics.

Nobuyoshi Kumagai (7829759), Michio Kuroda (22641220), Tosei Hanai (22641223), Masaki Fujita (25710), Takaaki Hino (22641226), Shunta Yorimoto (22641229), Sayaka Manta (22641232), Shuzo Nakagawa (22641235), Moe Yokoyama (22641238), Leon Tajima (22641241), Riku Ito (22641244), Hikaru Yamada (22641247), Kota Miura (53551), Makoto Kashima (7369595), Katsushi Yamaguchi (535058), Shuji Shigenobu (464699), Ryohei Furukawa (610857), Kiyono Sekii (5384378), Kazuya Kobayashi (845603)   +18 more
openalex   +1 more source

Statistical Summary of Programs [PDF]

Science, 1942
openaire   +2 more sources

Appendix A. Summary statistics for the distribution of trait values for both global data sets and Jasper Ridge (54 woody species).

, 2016
William K. Cornwell, Dylan W. Schwilk, David D. Ackerly   +2 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A Pleiotropy-Informed Bayesian False Discovery Rate adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics [PDF]

, 2015
James Liley, Chris Wallace
openalex   +1 more source