Results 181 to 190 of about 3,292,350 (321)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Integrative Mendelian randomization for detecting exposure-by-group interactions using group-specific and combined summary statistics. [PDF]

PLoS Genet
Xu K, Maydanchik N, Kang B, Chen J, Chen Q, Xu G, Tasaki S, Bennett DA, Chen LS.   +8 more
europepmc   +1 more source

Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies. [PDF]

Bioinformatics, 2023
Pham DT, Westerman KE, Pan C, Chen L, Srinivasan S, Isganaitis E, Vajravelu ME, Bacha F, Chernausek S, Gubitosi-Klug R, Divers J, Pihoker C, Marcovina SM, Manning AK, Chen H.   +14 more
europepmc   +1 more source

Summary statistics for attainment, leaver destinations and healthy living [PDF]

, 2012

core  

Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits [PDF]

, 2016
Nicholas Mancuso, Huwenbo Shi, Pagé C. Goddard, Gleb Kichaev, Alexander Gusev, Bogdan Paşaniuc   +5 more
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Calculating genetic risk scores directly from summary statistics with an application to type 1 diabetes. [PDF]

Bioinform Adv
Squires S, Weedon MN, Oram RA.
europepmc   +1 more source

GCTB SBayesR shrunk sparse linkage disequilibrium matrices for HM3 variants, summary statistics and predictors generated from "Improved polygenic prediction by Bayesian multiple regression on summary statistics" by Lloyd-Jones, Zeng et al. 2019.

, 2019
Luke R. Lloyd‐Jones
openalex   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Summary of CTV statistics.

, 2017
Joo Ji Hyeon, Kim Young Seok, Cho Byung Chul, Jeong Chi Young, Park Kyong Won, Jae Kim Hak, Yoon Won Sup, Yoon Mee Sun, Kim Ji-Yoon, Choi Jin Hwa, Choi Youngmin, Joo Young Kim   +11 more
openalex   +2 more sources