Results 191 to 200 of about 3,753,733 (329)

Statistical Summary of Programs [PDF]

Science, 1942
openaire   +2 more sources

Beyond summary statistics: extracting etiological insights from genome-wide association cohorts

, 2021
Jie Yuan
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Collaborative Inference for Accelerated Failure Time Model Using Clinical Center-Level Summary Statistics. [PDF]

Stat Med
Hu M, Shi X, Gong Z, Song PX.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Logica: A likelihood framework for cross-ancestry local genetic correlation estimation using summary statistics. [PDF]

Am J Hum Genet
Gao B, Li Z, Zhou X.
europepmc   +1 more source

SummaryAUC: a tool for evaluating the performance of polygenic risk prediction models in validation datasets with only summary level statistics [PDF]

, 2018
Lei Song, Aiyi Liu, Jianxin Shi
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Integrating gene expression with summary association statistics to identify susceptibility genes for 30 complex traits [PDF]

, 2016
Nicholas Mancuso, Huwenbo Shi, Pagé C. Goddard, Gleb Kichaev, Alexander Gusev, Bogdan Paşaniuc   +5 more
openalex   +1 more source

Additional file 4 of A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics

, 2021
Haojie Lu, Jiahao Qiao, Zhonghe Shao, Ting Wang, Shuiping Huang, Ping Zeng   +5 more
openalex   +1 more source