Results 211 to 220 of about 3,753,733 (329)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Beacon Reconstruction Attack: Reconstruction of genomes in genomic data-sharing beacons using summary statistics. [PDF]

Bioinformatics
Saleem K, Cicek AE, Sav S.
europepmc   +1 more source

Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics. [PDF]

Behav Genet, 2023
Williams CM, Poore H, Tanksley PT, Kweon H, Courchesne-Krak NS, Londono-Correa D, Mallard TT, Barr P, Koellinger PD, Waldman ID, Sanchez-Roige S, Harden KP, Palmer AA, Dick DM, Karlsson Linnér R.   +14 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Optimizing and benchmarking polygenic risk scores with GWAS summary statistics. [PDF]

Genome Biol
Zhao Z, Gruenloh T, Yan M, Wu Y, Sun Z, Miao J, Wu Y, Song J, Lu Q.   +8 more
europepmc   +1 more source

Summary wind statistics from NEWA WRF mesoscale ensemble

, 2020
Andrea N. Hahmann
openalex   +2 more sources

Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics [PDF]

, 2018
Gregory McInnes, Yosuke Tanigawa, Chris DeBoever, Adam Lavertu, Julia Olivieri, Matthew Aguirre, Manuel A. Rivas   +6 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

GWASBrewer: An R Package for Simulating Realistic GWAS Summary Statistics. [PDF]

Genet Epidemiol
Morrison J.
europepmc   +1 more source

Appendix 1. Summary Statistics [PDF]

, 2021
openaire   +1 more source