Results 221 to 230 of about 3,753,733 (329)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Characterizing substructure via mixture modeling in large-scale genetic summary statistics. [PDF]

Am J Hum Genet
Stoneman HR, Price AM, Trout NS, Lamont R, Tifour S, Pozdeyev N, Colorado Center for Personalized Medicine, Crooks K, Lin M, Rafaels N, Gignoux CR, Marker KM, Hendricks AE.   +12 more
europepmc   +1 more source

Executive summary: heart disease and stroke statistics--2010 update: a report from the American Heart Association.

Circulation, 2010
D. Lloyd‐Jones, R. Adams, Todd M. Brown, M. Carnethon, S. Dai, G. de Simone, T. Ferguson, E. Ford, K. Furie, C. Gillespie, Alan Go, K. Greenlund, Nancy Haase, S. Hailpern, P. Ho, V. Howard, B. Kissela, S. Kittner, D. Lackland, L. Lisabeth, A. Marelli, M. McDermott, J. Meigs, D. Mozaffarian, M. Mussolino, G. Nichol, V. Roger, W. Rosamond, R. Sacco, P. Sorlie, R. Stafford, T. Thom, S. Wasserthiel-Smoller, N. Wong, J. Wylie-Rosett   +34 more
semanticscholar   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Intrinsic dimension as a multi-scale summary statistics in network modeling. [PDF]

Sci Rep
Macocco I, Mira A, Laio A.
europepmc   +1 more source

Improved heritability partitioning and enrichment analyses using summary statistics with graphREML [PDF]

Hui Li, Tushar Kamath, Rahul Mazumder, Xihong Lin, Luke J. O’Connor   +4 more
openalex   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source

MUTATE: a human genetic atlas of multiorgan artificial intelligence endophenotypes using genome-wide association summary statistics. [PDF]

Brief Bioinform
Boquet-Pujadas A, Zeng J, Tian YE, Yang Z, Shen L, Zalesky A, Davatzikos C, MULTI Consortium, Wen J.   +8 more
europepmc   +1 more source

vcf_stats.py — Summary statistics and tumor mutation burden from VCF

B, Britt
openalex   +1 more source