Results 31 to 40 of about 3,753,733 (329)

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

Nucleic Acids Res., 2018
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide association studies enabling investigations to identify causal variants, understand disease mechanisms, and establish targets for novel therapies.
A. Buniello, J. MacArthur, M. Cerezo, Laura W. Harris, J. Hayhurst, Cinzia Malangone, A. McMahon, Joannella Morales, Edward Mountjoy, E. Sollis, D. Suveges, Olga Vrousgou, P. Whetzel, R. Amode, Jose A. Guillen, H. Riat, S. Trevanion, Peggy Hall, Heather Junkins, P. Flicek, Tony Burdett, L. Hindorff, Fiona Cunningham, H. Parkinson   +23 more
semanticscholar   +1 more source

Partitioning heritability by functional annotation using genome-wide association summary statistics

Nature Genetics, 2015
Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here we analyze a broad set of functional elements, including cell type–specific elements, to estimate their
H. Finucane, B. Bulik-Sullivan, A. Gusev, G. Trynka, Yakir A. Reshef, Po-Ru Loh, V. Anttila, Han Xu, C. Zang, K. Farh, S. Ripke, F. Day, S. Purcell, E. Stahl, S. Lindstrom, J. Perry, Y. Okada, S. Raychaudhuri, M. Daly, N. Patterson, B. Neale, A. Price   +21 more
semanticscholar   +1 more source

Assessment of the causal association between celiac disease and cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2022
BackgroundEpidemiological studies have reported inconsistent results of the association between celiac disease (CD) and cardiovascular diseases. Moreover, the causality remains largely unknown.
Jian Huang
doaj   +1 more source

A robust two‐sample transcriptome‐wide Mendelian randomization method integrating GWAS with multi‐tissue eQTL summary statistics

Genetic Epidemiology, 2021
By treating genetic variants as instrumental variables (IVs), two‐sample Mendelian randomization (MR) methods detect genetically regulated risk exposures for complex diseases using only summary statistics.
Kevin J. Gleason, Fan Yang, Lin S. Chen
semanticscholar   +1 more source

Summary statistics for fossil spider species taxonomy

ZooKeys, 2012
Spiders (Araneae) are one of the most species-rich orders on Earth today, and also have one of the longest geological records of any terrestrial animal groups, as demonstrated by their extensive fossil record.
David Penney, Jason Dunlop, Yuri Marusik
doaj   +1 more source

A tool for translating polygenic scores onto the absolute scale using summary statistics

medRxiv, 2021
There is growing interest in the clinical application of polygenic scores as their predictive utility increases for a range of health-related phenotypes.
Oliver Pain, A. Gillett, J. Austin, L. Folkersen, C. Lewis   +4 more
semanticscholar   +1 more source

On Exact and Approximate Approaches for Stochastic Receptor-Ligand Competition Dynamics—An Ecological Perspective

Mathematics, 2020
Cellular receptors on the cell membrane can bind ligand molecules in the extra-cellular medium to form ligand-bound monomers. These interactions ultimately determine the fate of a cell through the resulting intra-cellular signalling cascades.
Polly-Anne Jeffrey, Martín López-García, Mario Castro, Grant Lythe, Carmen Molina-París   +4 more
doaj   +1 more source

Inferring HIV Transmission Network Determinants Using Agent-Based Models Calibrated to Multi-Data Sources

Mathematics, 2021
(1) Background: Calibration of Simpact Cyan can help to improve estimates related to the transmission dynamics of the Human Immunodeficiency Virus (HIV).
David Niyukuri, Trust Chibawara, Peter Suwirakwenda Nyasulu, Wim Delva   +3 more
doaj   +1 more source

Overestimated prediction using polygenic prediction derived from summary statistics

BMC Genomic Data, 2023
Background When polygenic risk score (PRS) is derived from summary statistics, independence between discovery and test sets cannot be monitored. We compared two types of PRS studies derived from raw genetic data (denoted as rPRS) and the summary ...
David Keetae Park, Mingshen Chen, Seungsoo Kim, Yoonjung Yoonie Joo, Rebekah K. Loving, Hyoung Seop Kim, Jiook Cha, Shinjae Yoo, Jong Hun Kim   +8 more
doaj   +1 more source

A genome-wide cross-cancer meta-analysis highlights the shared genetic links of five solid cancers

Frontiers in Microbiology, 2023
Breast, ovarian, prostate, lung, and head/neck cancers are five solid cancers with complex interrelationships. However, the shared genetic factors of the five cancers were often revealed either by the combination of individual genome-wide association ...
Hongping Guo, Wenhao Cao, Yiran Zhu, Tong Li, Boheng Hu   +4 more
doaj   +1 more source