Results 71 to 80 of about 3,753,733 (329)
Frontiers in Genetics, 2021 While the promise of electronic medical record and biobank data is large, major questions remain about patient privacy, computational hurdles, and data access.
Jack M. Wolf +3 more
doaj +1 more source
Evaluating and improving heritability models using summary statistics
Nature Genetics, 2019 There is currently much debate regarding the best model for how heritability varies across the genome. The authors of GCTA recommend the GCTA-LDMS-I model, the authors of LD Score Regression recommend the Baseline LD model, and we have recommended the ...
D. Speed, J. Holmes, D. Balding
semanticscholar +1 more source
bioRxiv, 2020 Genetic correlation is the correlation of additive genetic effects on two phenotypes. It is an informative metric to quantify the overall genetic similarity between complex traits, which provides insights into their polygenic genetic architecture ...
Yiliang Zhang +5 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn +4 more
wiley +1 more source
Developmental Disorders in Children Recently Diagnosed With Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag +5 more
wiley +1 more source
Frontiers in Genetics, 2018 The relationship between growth and immune phenotypes has been presented in the context of physiology and energy allocation theory, but has rarely been explained genetically in humans.
Zhe Zhang +15 more
doaj +1 more source
Frontiers in Genetics, 2021 Motivation: Genome-wide association studies (GWAS) have achieved remarkable success in identifying SNP-trait associations in the last decade. However, it is challenging to identify the mechanisms that connect the genetic variants with complex traits as ...
Yi Yang, Kar-Fu Yeung, Jin Liu
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance It has been shown that human genomes can affect phenotype both directly (through inherited genetic variants) and indirectly (through parents and the family environment they create).
Yuchang Wu +8 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker +7 more
wiley +1 more source
sumrep: A Summary Statistic Framework for Immune Receptor Repertoire Comparison and Model Validation
Frontiers in Immunology, 2019 The adaptive immune system generates an incredible diversity of antigen receptors for B and T cells to keep dangerous pathogens at bay. The DNA sequences coding for these receptors arise by a complex recombination process followed by a series of ...
Branden J. Olson +13 more
doaj +1 more source