Results 81 to 90 of about 3,292,350 (321)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The Hierarchical Sparse Selection Model of Visual Crowding

Frontiers in Integrative Neuroscience, 2014
Because the environment is cluttered, objects rarely appear in isolation. The visual system must therefore attentionally select behaviorally relevant objects from among many irrelevant ones. A limit on our ability to select individual objects is revealed
Wesley eChaney, Jason eFischer, Jason eFischer, David eWhitney   +3 more
doaj   +1 more source

Local inhomogeneous weighted summary statistics for marked point processes [PDF]

, 2022
Nicoletta D’Angelo, Giada Adelfio, Jorge Mateu, Ottmar Cronie   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Federated Learning With Differential Privacy Based on Summary Statistics

Engineering Reports
In data analysis, privacy preserving is receiving more and more attention, privacy concerns results in the formation of “data silos”. Federated learning can accomplish data integrated analysis while protecting data privacy, it is currently an effective ...
Peng Zhang, Pingqing Liu
doaj   +1 more source

Statistical topological data analysis using persistence landscapes [PDF]

, 2015
We define a new topological summary for data that we call the persistence landscape. Since this summary lies in a vector space, it is easy to combine with tools from statistics and machine learning, in contrast to the standard topological summaries ...
Bubenik, Peter
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Additional file 4 of A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics

, 2021
Haojie Lu, Jiahao Qiao, Zhonghe Shao, Ting Wang, Shuiping Huang, Ping Zeng   +5 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Non-parametric indices of dependence between components for inhomogeneous multivariate random measures and marked sets

, 2016
We propose new summary statistics to quantify the association between the components in coverage-reweighted moment stationary multivariate random sets and measures.
van Lieshout, M. N. M.
core