Results 81 to 90 of about 3,753,733 (329)

Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

open access: yesNature Communications, 2016
Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its ...
A. Barbeira   +260 more
semanticscholar   +1 more source

An evaluation of time series summary statistics as features for clinical prediction tasks

open access: yesBMC Medical Informatics and Decision Making, 2020
Background Clinical prediction tasks such as patient mortality, length of hospital stay, and disease diagnosis are highly important in critical care research. The existing studies for clinical prediction mainly used simple summary statistics to summarize
Chonghui Guo, Menglin Lu, Jingfeng Chen
semanticscholar   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu   +20 more
wiley   +1 more source

Can Theory Improve the Scope of Quantitative Metazoan Metabarcoding?

open access: yesDiversity, 2015
Using high-throughput sequencing approaches to quantify biodiversity has a number of hurdles, in particular that the number of reads for a given taxon may not be proportional to the number of individuals of that taxon in a sample.
John P. Wares, Paula Pappalardo
doaj   +1 more source

Evaluation of A Phylogenetic Pipeline to Examine Transmission Networks in A Canadian HIV Cohort

open access: yesMicroorganisms, 2020
Modern computational methods using patient Human Immunodeficiency Virus type 1 (HIV-1) genetic sequences can model population-wide viral transmission dynamics. Accurate transmission inferences can play a critical role in the characterization of high-risk
Lauren Mak   +7 more
doaj   +1 more source

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser   +5 more
wiley   +1 more source

STATISTIC METHODS OF TOURIST INFORMATION SYSTEMATIZATION

open access: yesRussian Journal of Economics and Law, 2014
Objective: development of statistical methods to systematize information in tourist sphere. Methods: statistical monitoring, data summarizing and grouping.
A. O. Ovcharov
doaj  

Fully Bayesian tests of neutrality using genealogical summary statistics

open access: yesBMC Genetics, 2008
Background Many data summary statistics have been developed to detect departures from neutral expectations of evolutionary models. However questions about the neutrality of the evolution of genetic loci within natural populations remain difficult to ...
Drummond Alexei J, Suchard Marc A
doaj   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou   +10 more
wiley   +1 more source

Causal effects of socioeconomic traits on frailty: a Mendelian randomization study

open access: yesFrontiers in Medicine
BackgroundThe relationship between socioeconomic status and frailty has been extensively investigated in the literature, but it remains unclear whether a causal relationship exists.
Jian Huang   +4 more
doaj   +1 more source

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