Results 81 to 90 of about 351,224 (307)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Directional Global Three-part Image Decomposition
, 2015 We consider the task of image decomposition and we introduce a new model coined directional global three-part decomposition (DG3PD) for solving it. As key ingredients of the DG3PD model, we introduce a discrete multi-directional total variation norm and ...
Gottschlich, Carsten, Thai, Duy Hoang
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Forensic Sciences Research, 2018 Chrysomya megacephala (Fabricius, 1794) is the most abundant and predominant species which arrives and colonizes a cadaver first in most parts of China.
Yingna Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Shock and Vibration, 2020 A stable and accurate finite-difference discretization of first-order elastic wave equations is derived in this work. To simplify the origin and proof of the formulas, a symmetric matrix form (SMF) for elastic wave equations is presented.
Cheng Sun +3 more
doaj +1 more source
High-order accurate difference schemes for the Hodgkin-Huxley equations
, 2012 A novel approach for simulating potential propagation in neuronal branches with high accuracy is developed. The method relies on high-order accurate difference schemes using the Summation-By-Parts operators with weak boundary and interface conditions ...
Amsallem, David, Nordstrom, Jan
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
FAST NUMERICAL IMPLEMENTATION OF THE MDR TRANSFORMATIONS
Facta Universitatis. Series: Mechanical Engineering, 2018 In the present paper a numerical implementation technique for the transformations of the Method of Dimensionality Reduction (MDR) is described. The MDR has become, in the past few years, a standard tool in contact mechanics for solving axially-symmetric ...
Justus Benad
doaj +1 more source