Results 221 to 230 of about 46,190 (264)
Molecular recognition and induced dimerization of hnRNP A2/B1 truncations by G-quadruplex single strand DNA. [PDF]
Sci RepShahatibieke D +4 more
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Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases [PDF]
Angewandte Chemie - International Edition, 2018 AbstractSUMO is a post‐translational modifier critical for cell cycle progression and genome stability that plays a role in tumorigenesis, thus rendering SUMO‐specific enzymes potential pharmacological targets. However, the systematic generation of tools for the activity profiling of SUMO‐specific enzymes has proven challenging.
Monique P C Mulder +2 more
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Biochemical Society Transactions, 2007
Post-translational modification of cellular proteins by the SUMO (small ubiquitin-related modifier) is involved in numerous modes of regulation in widely different biological processes. In contrast with ubiquitination, SUMO conjugation is highly specific in terms of target lysine residues, but many aspects of substrate and lysine selection by the SUMO ...
J, Anckar, L, Sistonen
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Post-translational modification of cellular proteins by the SUMO (small ubiquitin-related modifier) is involved in numerous modes of regulation in widely different biological processes. In contrast with ubiquitination, SUMO conjugation is highly specific in terms of target lysine residues, but many aspects of substrate and lysine selection by the SUMO ...
J, Anckar, L, Sistonen
openaire +2 more sources
SUMO Signaling by Hypoxic Inactivation of SUMO-Specific Isopeptidases [PDF]
Cell Reports, 2016 Post-translational modification of proteins with ubiquitin-like SUMO modifiers is a tightly regulated and highly dynamic process. The SENP family of SUMO-specific isopeptidases comprises six cysteine proteases. They are instrumental in counterbalancing SUMO conjugation, but their regulation is not well understood.
Kristina Wagner +2 more
exaly +6 more sources
2010
Sumoylation, the covalent attachment of SUMO peptide to cellular proteins, is an essential regulator of protein function involved in a wide range of cellular events. Deregulation of the SUMO pathway is implicated in the pathogenesis of several diseases, so it is important to understand how this system is controlled.
Maderböck, K., Pichler, A.
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Sumoylation, the covalent attachment of SUMO peptide to cellular proteins, is an essential regulator of protein function involved in a wide range of cellular events. Deregulation of the SUMO pathway is implicated in the pathogenesis of several diseases, so it is important to understand how this system is controlled.
Maderböck, K., Pichler, A.
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SUMO Conjugation and SUMO Chain Formation by Plant Enzymes
2022SUMO conjugation is a conserved process of eukaryotes, and essential in metazoa. Similar to ubiquitylation, a SUMO-activating enzyme links to the SUMO carboxyl-terminal Gly in a thioester bond, and a SUMO-conjugating enzyme accepts activated SUMO and can transfer it to substrates.
Tomanov, Konstantin +3 more
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Genes and Cancer, 2010 Small ubiquitin-like modifiers (SUMO) conjugation to cellular proteins is a reversible posttranslational modification that mediates the protein's function, subcellular localization, and/or expression. The SUMO proteases (SENP) deconjugate modified proteins and thus are critical for maintaining the level of SUMOylated and un-SUMOylated substrates ...
Tasneem Bawa-Khalfe, Edward T H Yeh
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Ubiquitin and ubiquitin-like modifiers constitute one of the most versatile systems for the control of protein function by post-translational modifications. While the ubiquitin pathway has been very well characterized, our knowledge of SUMO and its mechanisms of action is still limited.
Rodrigo, Martín-Rufo +2 more
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Rodrigo, Martín-Rufo +2 more
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Trends in Biochemical Sciences, 2008
PHD fingers and bromodomains are found in close proximity to each other in many chromatin-associated proteins and can functionally synergize. Recently, it has been demonstrated that the PHD finger of the KAP1 co-repressor functions as an E3 SUMO ligase for the adjacent bromodomain.
Jamy, Peng, Joanna, Wysocka
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PHD fingers and bromodomains are found in close proximity to each other in many chromatin-associated proteins and can functionally synergize. Recently, it has been demonstrated that the PHD finger of the KAP1 co-repressor functions as an E3 SUMO ligase for the adjacent bromodomain.
Jamy, Peng, Joanna, Wysocka
openaire +2 more sources