Results 161 to 170 of about 28,340 (228)
Cell Proliferation, Volume 58, Issue 7, July 2025.PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang +9 more
wiley +1 more source
Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways. [PDF]
, 2018 Despite the similar enzyme cascade in the Ubiquitin and Ubiquitin-like peptide(Ubl) conjugation, the involvement of single or heterodimer E1 activating enzyme has been a mystery.
Gaieb, Zied +7 more
core
Cell Proliferation, Volume 58, Issue 7, July 2025.Lung cancer development involves mechanisms like reduced EGFR/EGF ubiquitination driving cancer cell behaviors and immune evasion via loss of PD‐1/PD‐L1 ubiquitination. Balancing ubiquitination and deubiquitination may be a potential therapeutic strategy. ABSTRACT Non‐small cell lung cancer (NSCLC) remains a leading cause of cancer mortality.
Guangyao Zhou +5 more
wiley +1 more source
Structural attributes in the conjugation of Ubiquitin, SUMO and RUB to protein substrates [PDF]
, 2002 Sandra Goettsch, Peter Bayer
openalex +1 more source
New Phytologist, Volume 247, Issue 2, Page 504-517, July 2025.Summary Repetitive DNA is a feature of all organisms, ranging from archaea and plants to humans. DNA repeats can be seen both in coding and in noncoding regions of the genome. Due to the recurring nature of the sequences, simple DNA repeats tend to be more prone to errors during replication and repair, resulting in variability in their unit length ...
Sridevi Sureshkumar +3 more
wiley +1 more source
Recent advances in proteomic workflows to interrogate the SUMOylome in plants
New Phytologist, Volume 247, Issue 1, Page 90-96, July 2025.Summary Protein posttranslational modifications (PTMs) are vital for regulating protein functions. SUMOylation, a PTM essential for plant survival, involves attaching a Small Ubiquitin‐like MOdifier (SUMO) to lysine residues of target proteins. SUMOylation influences stress tolerance, cell proliferation, protein stability, and gene expression.
Kishor D. Ingole +3 more
wiley +1 more source
A Synergy Control Motif within the Attenuator Domain of CCAAT/Enhancer-binding Protein α Inhibits Transcriptional Synergy through Its PIASy-enhanced Modification by SUMO-1 or SUMO-3 [PDF]
, 2003 Lalitha Subramanian +2 more
openalex +1 more source
New Phytologist, Volume 247, Issue 1, Page 233-248, July 2025.Summary Pathogenesis‐related (PR) proteins are diverse stress‐ or pathogen‐induced proteins. Some are associated with specialised metabolism, including proposed functions for anthocyanin biosynthesis. However, data are limited to a few angiosperm species, and the mode(s) of action are uncertain.
Yanfei Zhou +8 more
wiley +1 more source
Plant Biotechnology Journal, Volume 23, Issue 7, Page 2651-2666, July 2025.Summary Natural genetic variation can be used to improve important crop agronomic traits, and understanding the genetic basis of natural variation in fruit shape can help breeders develop pepper varieties that meet market demand. In this study, we identified a QTL controlling fruit length–width ratio by conventional genetic mapping, encoding a ...
Lianzhen Mao +15 more
wiley +1 more source
SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin μ gene expression [PDF]
, 2003 Gergana Dobreva +2 more
openalex +1 more source