Results 141 to 150 of about 49,192 (259)

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Left atrial functional recovery precedes volumetric reverse remodeling after TAVI by speckle tracking echocardiography. [PDF]

Sci Rep
Li G, Liu N, Sun W, Xu K, Wang B, Zhou W, Han Y.   +6 more
europepmc   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Robot-Assisted Osteotomy and Reconstruction with AR Guidance in Maxillofacial Reconstructive Surgery. [PDF]

Cyborg Bionic Syst
Cao S, Fan J, Shao L, Sun Q, Xu T, Ai D, Fu T, Xiao D, Song H, Zhang T, Yang J.   +10 more
europepmc   +1 more source

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, EarlyView.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Biotic and abiotic factors drive circadian migration patterns in Northern pintails across the Eurasian flyway. [PDF]

Mov Ecol
Cevenini D, Baroni D, Cecere JG, Panzarin L, Basso M, Franzoi A, Spina F, Pirrello S, De Pascalis F, Imperio S, Pilastro A, Serra L.   +11 more
europepmc   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

Vitamin D status and intake in early school-aged children is tracking from pregnancy-the Swedish GraviD-Child study. [PDF]

BMC Pediatr
Forsby M, Bärebring L, Amberntsson A, Dangardt F, Winkvist A, Augustin H.   +5 more
europepmc   +1 more source

Bipolar Palladium Membrane Enabling Crossover‐Free Selective Proton Transport

Advanced Science, EarlyView.
This study introduces a crossover‐free bipolar palladium membrane that transports protons selectively via reversible Pd/PdHx absorption–desorption and lattice hydrogen diffusion, overcoming the conductivity–selectivity trade‐off of polymer membranes. It enables water‐fed Li‐mediated ammonia synthesis, achieving 51% Faradaic efficiency and stable 12 h ...
Jiyeon Baek, Yeongbae Jeon, Seunga Lee, Ahee Choi, Joonmok Shim, Kyungho Lee, Ho Woun Jung, Sun Hyung Kim, Churl Hee Cho, Hyung Chul Yoon, Yun Jeong Hwang, Jae Hyung Kim   +11 more
wiley   +1 more source

Underwater Multi-Target Tracking and Behavioral Rhythm Analysis of Chinese Giant Salamander Based on TransTrack-OC-SORT. [PDF]

Animals (Basel)
Sun N, Yang X, Xie M, Qian H, Chen J.
europepmc   +1 more source