Results 1 to 10 of about 2,344 (157)
Clonal Mosaicism of Mitochondrial DNA Heteroplasmy as a Molecular Clock of Aging. [PDF]
Aging CellMitochondrial DNA mutations diverge by tissue dynamics across lifespan: dividing tissues accumulate pervasive point mutations via clonal stem‐cell expansion, whereas post‐mitotic tissues harbor clonally expanded large‐scale deletions, both culminating in age‐dependent, threshold‐limited respiratory failure.
Chang R +5 more
europepmc +2 more sources
The GLP-1-Mitochondria Axis in Metabolic Aging. [PDF]
Aging CellGlucagon‐like peptide‐1 receptor agonists engage AMPK–PGC‐1α signaling to remodel mitochondrial biogenesis, dynamics, and quality control, but downstream effects are context‐dependent and tissue‐specific rather than uniformly receptor‐proximal. Whether this proposed mitochondria‐incretin axis reflects a novel geroscience mechanism or indirect metabolic
Chang R, Tsai AP, Wang B, Li CJ.
europepmc +2 more sources
A dual gating mechanism controls target-strand cleavage in Cas12j: Implications for engineering efficient nickases. [PDF]
Protein SciAbstract The rapid expansion of CRISPR technologies has unveiled a diverse repertoire of RNA‐guided endonucleases, among them the compact Cas12j, which has emerged as a promising genome‐editing tool. Cas12j cleaves the two DNA strands sequentially; however, the molecular mechanism that regulates this cleavage remains incompletely understood.
Karvounis IG, Daskalakis V.
europepmc +2 more sources
Use of the PROMIS and Neuro-QoL to Evaluate Health-Related Quality of Life following Unilateral Subthalamic Deep Brain Stimulation for Parkinson's Disease. [PDF]
Mov Disord Clin PractAbstract Background Subthalamic nucleus deep brain stimulation (STN DBS) improves Parkinson's disease (PD)‐related motor symptoms, but how STN DBS impacts various aspects of patient‐perceived health‐related quality of life (HRQoL) is less clear. The Patient‐Reported Outcome Measurement Instrument (PROMIS) and Quality of Life in Neurological Disorders ...
Brinkerhoff SA +10 more
europepmc +2 more sources
Archaeoastronomy and Ancient Technologies, 2022 This article proposes a mathematical model of an inverted analemmatic sundial, provides formulas for calculating the coordinates of their hour markers.
Vodolazhskaya, L.N.
doaj +2 more sources
Earth and Space Science, 2021 In this paper, we present the results obtained in the determination of the true north direction on Mars by using a gnomon on the InSight mission and compare the measurements with either the North determination from the Inertial Measurement Unit and ...
John Clinton +2 more
exaly +2 more sources
Top Cogn SciAbstract Many core human activities require an understanding of time. To coordinate rituals, plan harvests and hunts, recall histories, keep appointments, and follow recipes, we need to grapple with invisible temporal structures like durations, sequences, and cycles. No other species seems to do this.
Cooperrider K.
europepmc +2 more sources
Remote Sensing, 2020 A large part of the archaeological remains still to be discovered and excavated are not in remote and depopulated areas of the earth but are often beneath urban centres that have buried them with centuries of debris and later constructions. Excavating in
Grazia Tôsi +2 more
exaly +3 more sources
Inverted analemmatic sundial of the Bronze Age [PDF]
Archaeoastronomy and Ancient Technologies, 2022 This article describes the study, using the methods of digital and computational archeology, of a Bronze Age limestone slab with cup marks, discovered during the archaeological excavations of kurgan 1 of the kurgan grave field Prolom II, located in the ...
L.N. Vodolazhskaya
doaj +1 more source