Results 191 to 200 of about 12,813 (239)

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

From qualitative prediction to quantitative insight: combined meteorological patterns and regional dynamics of severe fever with thrombocytopenia syndrome in Liaoning Province, China, 2010-2024. [PDF]

Infect Dis Model
Yu N, Deng B, Zhang X.
europepmc   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Seasonal and Meteorological Influences on Stroke Incidence and Outcomes in a Tropical Urban Setting: A 10-Year Retrospective Study in Douala, Cameroon. [PDF]

Geohealth
Magnerou AM, Massi Gams D, Matega ALS, Lamou Bila Gueumekane E, Sini V, Doumbe JN, Kuate-Tegueu C, Njankouo Mapoure Y.   +7 more
europepmc   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

Life History and the Relation Between Population Dynamics and Meteorological Factors of <i>Hyphantria cunea</i> (Lepidoptera: Erebidae: Arctiidae) in Shanghai, China. [PDF]

Insects
Tang S, Li Z, Huang G, Han Y, Hao D.
europepmc   +1 more source

Analysis of sunshine duration and surface temperature of a building in urban areas using a sunshine duration model and easurements

Journal of the Geological Society of Korea
Jung-Eun Kang, Ju-Hwan Rho, Ji-Eun Lee, Sung-hee Kim, Chae-Rin Kim, Jeong-Min Son, Min-Jae Jo, Eun-Seo Jo, Soo-Jin Park, Jae-Jin Kim   +9 more
openaire   +1 more source

Ga Doping Enables Precision Alloy‐to‐Wire Regulation: Synergistic Enhancement of the Mechanical Properties of CuSn Alloy and the Superconducting Properties of Nb3Sn

Advanced Science, EarlyView.
By adjusting Ga's doping in Cu–Sn alloy, an ultra‐high elongation of 100.8% is achieved in first time. Ga forms a stable solid solution structure and a stronger electron exchange with Cu. This enhances strength‐ductility synergistically by tuning SFE to balance twinning and slip.
Dazhuo Song, Juntao Zou, Jiayue Zhang, Xinhang Liang, Mengyu Shan, Yifan Liu, Jingqi Feng, Tong Dang, Lin Shi, Yuxuan Wang, Yuchen Song, Rong Fei, Shaodong Sun, Zhe Zhang, Lei Zhu, Lixing Sun   +15 more
wiley   +1 more source

Impact of meteorological factors on influenza incidence in Wuxi from 2014 to 2019: a time series and comprehensive analysis. [PDF]

Front Public Health
He M, Wang Y, Ding X, Gao Y, Shi C.
europepmc   +1 more source

Seasonal and Environmental Determinants of Maternal and Neonatal Vitamin D Status: A Cross-Sectional Observational Cohort Study in Urban Greece. [PDF]

Healthcare (Basel)
Kokkinari A, Dagla M, Gourounti K, Sarantaki A, Kirkou G, Iliadou M, Antoniou E, Iatrakis G.   +7 more
europepmc   +1 more source