Results 151 to 160 of about 1,288,962 (254)

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source

Apple fruit diameter and length estimation by using the thermal and sunshine hours approach and its application to the digital orchard management information system. [PDF]

PLoS One, 2015
Li M, Chen M, Zhang Y, Fu C, Xing B, Li W, Qian J, Li S, Wang H, Fan X, Yan Y, Wang Y, Yang X.   +12 more
europepmc   +1 more source

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

Critical engagement on the selection and reporting of biometeorological indices. [PDF]

Int J Biometeorol
Fitchett JM.
europepmc   +1 more source

Seasonal variation in the incidence rate of tuberculous meningitis is associated with sunshine hours. [PDF]

Epidemiol Infect, 2013
Visser DH, Schoeman JF, VAN Furth AM.
europepmc   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Sun Exposure and Asthma Prevalence in Spanish Schoolchildren and Adolescents in the Global Asthma Network (GAN) Phase I Study: A Semi-Individual Cross-Sectional Study. [PDF]

J Clin Med
Arnedo-Pena A, Fattahi S, Aguinaga-Ontoso I, Bercedo-Sanz A, González-Díaz C, López-Silvarrey Varela A, Martínez-Torres AE, Pellegrini-Belinchón J, Sánchez-Solís M, García-Marcos L, The Spanish Gan Group.   +10 more
europepmc   +1 more source

Coral‐Biomimetic Structured Organic Electro‐Oxidations With Exceptional High‐Current Catalytic Performance

Advanced Science, EarlyView.
A strategy for energy‐efficient hydrogen production coupled with biomass valorization via organic electrooxidation reactions is reported. A bio‐inspired multiscale coral‐like heterostructure catalyst delivers record‐breaking OEOR performance enabled by a dual‐copper synergistic Cu+/Cu2+–Ni mechanism, establishing a universal architectural and ...
Chaoqun Pei, Tao Zhang, Congrui Yang, Yutao Tan, Zhengjie Chen, Yuyang Qian, Xiaoyu Wu, Xiaodi Liu, Xiong Liang, Jie Dong, Yongbin Guo, Haibo Ke, Wenqing Ruan, Zhenxuan Zhang, Tao Feng, Jing Peng, Jiang Ma, Baoan Sun   +17 more
wiley   +1 more source

Extreme low temperature is the key meteorological limiting factor for winter wheat yield in Shihezi. [PDF]

Front Plant Sci
Zhang S, Hu H, Peng J, Zhai J, Yang M.
europepmc   +1 more source