Results 41 to 50 of about 71,643 (226)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Nucleation threshold and deactivation mechanisms of nanoscopic cavitation nuclei [PDF]
, 2009 The acoustic nucleation threshold for bubbles trapped in cavities has theoretically been predicted within the crevice theory by Atchley and Prosperetti [“The crevice model of bubble nucleation,” J. Acoust. Soc. Am. 86, 1065 (1989)].
Andrea Prosperetti +4 more
core +5 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Superradiant scattering in fluids of light
, 2019 We theoretically investigate the scattering process of Bogoliubov excitations on a rotating photon-fluid. Using the language of Noether currents we demonstrate the occurrence of a resonant amplification phenomenon, which reduces to the standard ...
Faccio, Daniele +3 more
core +1 more source
Phenomenological Fluids from Interacting Tachyonic Scalar Fields [PDF]
, 2013 In this paper we are interested to consider mathematical ways to obtain different phenomenological fluids from two-component Tachyonic scalar fields. We consider interaction between components and investigate problem numerically.
Farahani, H. +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Coupling mechanisms of fracture propagation and proppant transport indeep coalbed methane reservoirs
Meitian dizhi yu kantanObjectives and MethodsDeep coalbed methane (CBM) reservoirs commonly exhibit well-developed beddings, strong mechanical heterogeneity, and high in-situ stress gradients. These characteristics result in pronounced nonlinear fracture propagation and strong
Xiaodong GUO +6 more
doaj +1 more source
Surface waves enhance particle dispersion
, 2019 We study the horizontal dispersion of passive tracer particles on the free surface of gravity waves in deep water. For random linear waves with the JONSWAP spectrum, the Lagrangian particle trajectories are computed using an exact nonlinear model known ...
Farazmand, Mohammad +1 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Solid-fluid transition in a granular shear flow [PDF]
, 2004 The rheology of a granular shear flow is studied in a quasi-2d rotating cylinder. Measurements are carried out near the midpoint along the length of the surface flowing layer where the flow is steady and non-accelerating. Streakline photography and image
Ashish V. Orpe +5 more
core +2 more sources