Results 111 to 120 of about 3,241,507 (337)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Bicuspid pulmonary and bicuspid aortic valve in association with Gasul phenomenon (triple combination): a case report and literature review

The Egyptian Heart Journal
Background Congenital heart disease (CHD) is a significant health concern affecting approximately 1% of live births. Among these anomalies, bicuspid aortic valve (BAV) is the most prevalent, while bicuspid pulmonary valve (BPV) remains exceptionally rare.
Uma Devi Karuru, T. Naveen, Sai Kumar Mysore, Sadanand Reddy Tummala, Ashirbad Parhi, Kiran Kumar Kanjerla   +5 more
doaj   +1 more source

Spontaneous mesenteric hematoma: Case report and review literature of a rare clinical entity

Radiology Case Reports
Spontaneous mesenteric hematomas (SMH) are not a common entity. Here we describe a case of 64 year old woman who presented with a vague abdominal pain and diffuse tenderness.
Gyan Chand, MD, Karan Kapoor, DNB, B.R. Goyal, MD, Archana Mathur, MD, Vineet Marwah, MD, Manjari Jaiswal, MD, Bhuvnesh Guglani, MD   +6 more
doaj   +1 more source

NTIRE 2017 Challenge on Single Image Super-Resolution: Methods and Results

2017 IEEE Conference on Computer Vision and Pattern Recognition Workshops (CVPRW), 2017
This paper reviews the first challenge on single image super-resolution (restoration of rich details in an low resolution image) with focus on proposed solutions and results. A new DIVerse 2K resolution image dataset (DIV2K) was employed.
Radu Timofte, E. Agustsson, L. Gool, Ming-Hsuan Yang, Lei Zhang, Bee Lim, Sanghyun Son, Heewon Kim, Seungjun Nah, Kyoung Mu Lee, Xintao Wang, Yapeng Tian, K. Yu, Yulun Zhang, Shixiang Wu, Chao Dong, Liang Lin, Y. Qiao, Chen Change Loy, Woong Bae, J. Yoo, Yoseob Han, J. C. Ye, Jae-Seok Choi, Munchurl Kim, Yuchen Fan, Jiahui Yu, Wei Han, Ding Liu, Haichao Yu, Zhangyang Wang, Humphrey Shi, Xinchao Wang, Thomas S. Huang, Yunjin Chen, K. Zhang, W. Zuo, Zhimin Tang, Linkai Luo, Shaohui Li, Min Fu, Lei Cao, Wen Heng, Giang Bui, Truc Le, Y. Duan, D. Tao, Ruxin Wang, Xu Lin, Jianxin Pang, Jinchang Xu, Yu Zhao, Xiangyu Xu, Jin-shan Pan, Deqing Sun, Yujin Zhang, Xibin Song, Yuchao Dai, Xueying Qin, X. Huynh, Tiantong Guo, Hojjat Seyed Mousavi, T. Vu, V. Monga, Cristóvão Cruz, K. Egiazarian, V. Katkovnik, Rakesh Mehta, A. Jain, Abhinav Agarwalla, C. Praveen, Ruofan Zhou, Hongdiao Wen, Chen Zhu, Zhiqiang Xia, Zhengtao Wang, Qi Guo   +76 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Imaging Spectrum of Unusual Pineal Region Masses: A Short Series of Four Cases

Indian Journal of Neurosurgery, 2017
Pineal tumors are rare intracranial neoplasm with germ cell tumors and pineal parenchymal tumors being the predominant type, seen in 80 to 90% of cases. Only a few cases of glioblastomas have been reported.
Anandamoyee Dhar, Ruchi Jain, Bipin Walia, Urmi Mukherjee, Bharat Aggarwal   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source