Results 91 to 100 of about 3,652,577 (286)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Rapid whole-heart CMR with single volume super-resolution

Journal of Cardiovascular Magnetic Resonance, 2020
Background Three-dimensional, whole heart, balanced steady state free precession (WH-bSSFP) sequences provide delineation of intra-cardiac and vascular anatomy. However, they have long acquisition times.
Jennifer A. Steeden, Michael Quail, Alexander Gotschy, Kristian H. Mortensen, Andreas Hauptmann, Simon Arridge, Rodney Jones, Vivek Muthurangu   +7 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Diffusion Models, Image Super-Resolution, and Everything: A Survey [PDF]

IEEE Transactions on Neural Networks and Learning Systems
Diffusion models (DMs) have disrupted the image super-resolution (SR) field and further closed the gap between image quality and human perceptual preferences.
Brian B. Moser, Arundhati S. Shanbhag, Federico Raue, Stanislav Frolov, Sebastián M. Palacio, Andreas Dengel   +5 more
semanticscholar   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Long-Distance Object Recognition With Image Super Resolution: A Comparative Study

IEEE Access, 2018
Monitor systems are ubiquitously deployed in public areas. However, monitor systems face a major challenge regarding long-distance object recognition. Super-resolution constitutes a popular choice to address this challenge. Since super-resolution methods
Xiaomin Yang, Wei Wu, Kai Liu, Pyoung Won Kim, Arun Kumar Sangaiah, Gwanggil Jeon   +5 more
doaj   +1 more source

End-to-End Learning of Video Super-Resolution with Motion Compensation

, 2017
Learning approaches have shown great success in the task of super-resolving an image given a low resolution input. Video super-resolution aims for exploiting additionally the information from multiple images. Typically, the images are related via optical
A Kappeler, BC Song, C Dong, C Dong, C Liu, H Takeda, J Yang, SD Babacan, WT Freeman   +8 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Focusing super resolution on the cytoskeleton [version 1; referees: 3 approved]

F1000Research, 2016
Super resolution imaging is becoming an increasingly important tool in the arsenal of methods available to cell biologists. In recognition of its potential, the Nobel Prize for chemistry was awarded to three investigators involved in the development of ...
Eric A. Shelden, Zachary T. Colburn, Jonathan C.R. Jones   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source