Results 81 to 90 of about 1,792,234 (236)

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5 [PDF]

, 2013
Postmortem studies have revealed a downregulation of the transcription factor Pax5 in GABAergic neurons in bipolar disorder, a neurodevelopmental disorder, raising the question whether Pax5 in GABAergic neurons has a role in normal brain development.
Asada, Benes, Bouchard, Ciani, Condie, Edmiston, Estivill-Torrus, Funahashi, Homanics, Horcher, Kempton, Louvi, Ma, Machon, Makiyama, Matsumoto, Meduri, Miller, Muyrers, Novak, Oh, Pfeffer, Rosa, Rowitch, Schwarz, Srinivas, Tamamaki, Tashiro, Tashiro, Thomas, Urbanek, Wojcik, Wurst, Ye, Zygourakis   +34 more
core   +2 more sources

International Veterinary Epilepsy Task Force recommendations for systematic sampling and processing of brains from epileptic dogs and cats [PDF]

, 2015
Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities.
A Jeans, A Katelaris, A Klang, A Pakozdy, A Pakozdy, A Pitkanen, A Woznicka, Akos Pakozdy, AM Wahle, Andrea Fischer, Andrea Tipold, Clare Rusbridge, DM Kowalska, Edward E. Patterson, ES Park, Eva Wagner, F Reinoso-Suárez, Francisco Fernández-Flores, G Isoardo, H Potschka, H Urbach, Heidrun Potschka, HO Lüders, Holger A. Volk, I Blumcke, I Toyoda, IK Hwang, J O’Muircheartaigh, Jacques Penderis, JE Cavazos, JH Margerison, JN Kornegay, JY Cheong, K Baiker, K Kobow, Karen Muñana, Kaspar Matiasek, L Wang, LP Hudson, Luisa De Risio, M Fischer, M Manford, M Oehmichen, M Sasaki, M Singer, M Thom, M Thom, M Wolf, Marco Rosati, Martí Pumarola i Batlle, ME Milne, Mette Berendt, Michael Podell, MP Witter, N Shihab, PS Buckmaster, R Adamec, R Crooks, RE Adamec, RE Adamec, RM Packer, RN Auer, Robyn G. Farquhar, S Lomoio, S Schriefl, Sam Long, Simon Platt, Sofie F. M. Bhatti, SY Bando, T Kuwabara, TS Jokinen, U Seneviratne, VA Gil, Veronika M. Stein, Y Masuo, Z Ahmed   +75 more
core   +7 more sources

Association of Reduced Brain Metabolism With Motor Function and Survival in Amyotrophic Lateral Sclerosis Patients With Neurofilament Heavy (NEFH) Gene Mutation

European Journal of Neurology, Volume 32, Issue 7, July 2025.
NEFH‐ALS had brain glucose hypometabolism of the cortex‐striatum/limbic system‐brainstem circuit, correlated with motor function, cognition, and depression. Brain glucose hypometabolism could lead to impairment of motor function, which was mediated by cognition and depression.
Xinyu Song, Xueying Wang, Fan Hu, Pan Liu, Ziqin Liu, Jiping Yi, Renxu Xu, Wenfeng Cao, Yuanchao Zhang, Junling Wang, Alessandro Grecucci, Xiaoping Yi, Bihong T. Chen   +12 more
wiley   +1 more source

Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Grik1) gene of a genetically audiogenic seizure model

Frontiers in Molecular Neuroscience
Genetic abnormalities affecting glutamate receptors are central to excitatory overload-driven neuronal mechanisms that culminate in seizures, making them pivotal targets in epilepsy research.
Sandra M. Díaz-Rodríguez, Sandra M. Díaz-Rodríguez, Sandra M. Díaz-Rodríguez, M. Javier Herrero-Turrión, M. Javier Herrero-Turrión, M. Javier Herrero-Turrión, Carlos García-Peral, Carlos García-Peral, Ricardo Gómez-Nieto, Ricardo Gómez-Nieto, Ricardo Gómez-Nieto   +10 more
doaj   +1 more source

Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease [PDF]

, 2013
Recent studies suggest a variety of factors characterize substantia nigra neurons vulnerable to Parkinson's disease, including the transcription factors pituitary homeobox 3 (Pitx3) and orthodenticle homeobox 2 (Otx2) and the trophic factor receptor ...
Andersson, Bergman, Bradford, Bäckman, Charles Watson, Chu, Chu, Chung, Chung, Cotrufo, Darios, Deniz Kirik, Di Salvio, Di Salvio, Dickson, Double, Fearnley, Franklin, Fuchs, Gad, Garcia-Reitbock, George Paxinos, Gibb, Glenda M. Halliday, Greene, Halliday, Helen M. Cooper, Hwang, Kay L. Double, Kim, Kim, Korotkova, Lachlan H. Thompson, Lai Wing Sun, Le, Lebel, Lesnick, Lin, Manitt, Matsuda, Mcritchie, Nagahara, Nunes, Orme, Osborne, Paxinos, Prensa, Rangasamy, Reyes, Saucedo-Cardenas, Shatzmiller, Simeone, Simon, Simon, Smidt, Smidt, Smidt, Stefanie Reyes, Sullivan, Tcherkezian, Thomas, Van Den Munckhof, Veronica Cottam, Xu, Yang, Yuhong Fu, Zhao   +66 more
core   +1 more source

Neuronal activity modulates the expression of secretagogin, a Ca2+ sensor protein, during mammalian forebrain development

Acta Physiologica, Volume 241, Issue 5, May 2025.
Abstract Aim Because of their stable expression, some EF‐hand Ca2+‐binding proteins are broadly used as histochemical markers of neurons in the nervous system. Secretagogin is a member of “neuron‐specific” Ca2+‐sensor proteins, yet variations in its expression due, chiefly, to neuronal activity remain ambiguous.
János Hanics, Evgenii O. Tretiakov, Roman A. Romanov, Anna Gáspárdy, Zsófia Hevesi, Robert Schnell, Tibor Harkany, Alán Alpár   +7 more
wiley   +1 more source

Central Involvement in Pure Autonomic Failure: Insights from Neuromelanin‐Sensitive Magnetic Resonance Imaging and 18F‐Fluorodopa‐Positron Emission Tomography

Movement Disorders, Volume 40, Issue 4, Page 716-726, April 2025.
Abstract Background Central synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), involve alpha‐synuclein accumulation and dopaminergic cell loss in the substantia nigra (SN) and locus coeruleus (LC).
Paula Trujillo, Kaitlyn R. O'Rourke, Olivia C. Roman, Alexander K. Song, Kilian Hett, Amy Cooper, Bonnie K. Black, Manus J. Donahue, Cyndya A. Shibao, Italo Biaggioni, Daniel O. Claassen   +10 more
wiley   +1 more source

Tectal etiology for irrepressible saccades: a case study in a Rhesus monkey [v1; ref status: indexed, http://f1000r.es/we]

F1000Research, 2013
Brain circuits controlling eye movements are widely distributed and complex. The etiology of irrepressible square wave saccades is not fully understood and is likely different for different neuropathologies.
James W Gnadt, Christopher T Noto, Jagmeet S Kanwal   +2 more
doaj   +1 more source

Connecting the Brain to Itself through an Emulation. [PDF]

, 2017
Pilot clinical trials of human patients implanted with devices that can chronically record and stimulate ensembles of hundreds to thousands of individual neurons offer the possibility of expanding the substrate of cognition.
Serruya, Mijail D.
core   +3 more sources

Glaucoma animal models in rabbits: State of the art and perspectives—A review

Animal Models and Experimental Medicine, Volume 8, Issue 3, Page 429-440, March 2025.
Glaucoma, a visual thief, is characterized by elevated intraocular pressure (IOP) and loss of retinal ganglion cells (RGCs). Selecting suitable animals for preclinical models is of great significance in research on the prevention, early screening, and effective treatments of glaucoma.
Rong Hu, Kai Wu, Jian Shi, Juan Yu, Xiao‐lei Yao   +4 more
wiley   +1 more source