PrOMet: Accurate and Robust Metal‐Binding Site and Type Prediction
PrOMet is a two‐stage deep learning framework for jointly predicting metal‐binding sites and ion identities from protein structures. Surface candidate sites are first pruned, followed by refinement of the most probable sites and metal types. This hierarchical strategy enables robust and accurate metal prediction for cryo‐EM and AlphaFold‐derived ...
Gangeun Park, Chaok Seok, Hahnbeom Park
wiley +1 more source
EAAT2 Expression in the Hippocampus, Subiculum, Entorhinal Cortex and Superior Temporal Gyrus in Alzheimer's Disease. [PDF]
Yeung JHY +6 more
europepmc +1 more source
T-2 RELAXATION TIMES IN THE SUPERIOR TEMPORAL GYRUS OF INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS AND THEIR ASSOCIATIONWITH AUDITORY ...
Stephen J Wood (6611390) +5 more
core
An Integrated Artificial Intelligence Framework for Nanomedicine Engineering
This review outlines a closed‐loop AI ecosystem for nanomedicine engineering. By synergizing multimodal data harmonization, objective‐driven AI architectures, and automated high‐throughput validation, this “Design‐Make‐Test‐Analyze” (DMTA) workflow transforms traditional heuristic formulation into a predictive, self‐optimizing paradigm, accelerating ...
Meichen Dong +10 more
wiley +1 more source
Superior temporal gyrus and cerebellar loops predict nonsuicidal self-injury in major depressive disorder patients by multimodal neuroimaging. [PDF]
Kang L +13 more
europepmc +1 more source
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng +17 more
wiley +1 more source
Blunted superior temporal gyrus activity to negative emotional expression after mindfulness-based cognitive therapy for late-life depression. [PDF]
Liu W +9 more
europepmc +1 more source
Flexible Integration of Structurally Diverse Spatial Multi‐Omics With AgaeSMO
AgaeSMO is a versatile and robust deep learning framework for flexible cross‐integration of spatial multi‐omics data. Leveraging a GATs network with a graph attention module, it learns joint embedding across diverse modalities, enabling integration of both structurally paired (e.g., spatial transcriptome‐epigenome, transcriptome‐proteome, transcriptome‐
Kunpeng Liu +9 more
wiley +1 more source
Superior temporal gyrus functional connectivity predicts transcranial direct current stimulation response in Schizophrenia: A machine learning study. [PDF]
Paul AK +10 more
europepmc +1 more source

