Results 151 to 160 of about 874,608 (238)

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

A case report of Pallister-Killian syndrome with an unusual mosaic supernumerary marker chromosome 12 with interstitial 12p13.1-p12.1 duplication. [PDF]

Front Genet
Karamysheva TV, Lebedev IN, Minaycheva LI, Nazarenko LP, Kashevarova AA, Fedotov DA, Skryabin NA, Lopatkina ME, Cheremnykh AD, Fonova EA, Nikitina TV, Sazhenova EA, Skleimova MM, Kolesnikov NA, Drozdov GV, Yakovleva YS, Seitova GN, Orishchenko KE, Rubtsov NB.   +18 more
europepmc   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

A maternally derived complex small supernumerary marker chromosome involving chromosomes 8 and 14: case report and review of the literature. [PDF]

Front Genet
Ouboukss F, El Amrani Z, Bouchahta H, Ratbi I, Sbiti A, Liehr T, Sefiani A, Natiq A.   +7 more
europepmc   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

A unified formulation for home healthcare routing and scheduling problems

International Transactions in Operational Research, EarlyView.
Abstract Home Healthcare is an essential component of healthcare systems, where caregivers visit patients' homes to deliver services. While presenting advantages with respect to institutional care, such as being cost‐effective and alleviating family burdens, it presents challenges in scheduling and routing caregivers efficiently.
Sara Ceschia, Francesca Da Ros, Luca Di Gaspero, Simona Mancini, Vittorio Maniezzo, Roberto Montemanni, Roberto Maria Rosati, Andrea Schaerf   +7 more
wiley   +1 more source

Molecular cytogenetic characterization of a mosaic small supernumerary marker chromosome derived from chromosome Y in an azoospermic male: A case report. [PDF]

Medicine (Baltimore), 2019
Zhang H, Liu X, Geng D, Yue F, Jiang Y, Liu R, Wang R.   +6 more
europepmc   +1 more source

Do the biological characteristics of trout (Salmo trutta) smolts influence their spring migration timing and maiden marine sojourn duration?

Journal of Fish Biology, EarlyView.
Abstract Anadromous salmonids migrate seaward to exploit feeding and growth opportunities in marine habitats, yet how smolt biological characteristics influence their marine migratory behavior remains poorly understood. This study used 9 years of trout (Salmo trutta) population monitoring data from 15,595 tagged age‐0+ parr, 1033 smolts detected ...
Jonathan P. Gillson, Robert E. Blackwell, Stephen D. Gregory, Jessica E. Marsh, Tea Bašić, Sophie A. M. Elliott, R. Andrew King, David L. Maxwell, William D. Riley, Jamie R. Stevens, Alan M. Walker, Rasmus B. Lauridsen   +11 more
wiley   +1 more source

Characterization of a Small Supernumerary Marker Chromosome Derived from Xq28 and 14q11.2 Detected Prenatally. [PDF]

Case Rep Obstet Gynecol, 2018
Hasegawa A, Samura O, Sato T, Matsuoka T, Ito Y, Kajiwara K, Aoki H, Inage Y, Kobayashi M, Okamoto A.   +9 more
europepmc   +1 more source

ATXR5 and ATXR6 restrict meiotic crossover formation within heterochromatin in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The Arabidopsis H3K27 mono‐methyltransferases ATXR5 and ATXR6 repress crossovers within meiotic heterochromatin, are required for heterochromatin condensation and H3K27me1 establishment, and specifically influence the maintenance of DNA methylation in meiocytes.
Jun Zhang, Yue Yu, Han Wang, Meiling Li, Dingning Li, Chenjiang You, Yingxiang Wang, Cong Wang   +7 more
wiley   +1 more source