Results 201 to 210 of about 52,700 (275)

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Critical Points in the Noiseberg Achievable Region of the Gaussian Z-Interference Channel. [PDF]

Entropy (Basel)
Costa MHM, Nair C, Ng D.
europepmc   +1 more source

Genetic dissection reveals distinct contributions of the eS31 N‐terminal domain to translational accuracy in Saccharomyces cerevisiae

The FEBS Journal, EarlyView.
The eukaryote‐specific N‐terminal domain (NTD) of eS31 uses two distinct strategies to maintain translation fidelity. During elongation, a positively charged “hotspot” fine‐tunes the selection of incoming aa‐tRNA. During termination, the entire NTD acts as a structural scaffold to ensure the correct positioning of the release factor eRF1.
Qingxuan Gao, Hiroshi Otsuka, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Transformer-Based Nonlinear Blind Source Separation for Anti-Jamming in DSSS Satellite Communications. [PDF]

Sensors (Basel)
Sun X, Li C, Li J, Su Q.
europepmc   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Transformation method of Φ-OTDR optical fiber strain and tunnel liner strain and its application in tunnel safety monitoring. [PDF]

Sci Rep
Cao K, Xie Z, Zhou F, Wang X, Tang J, Wang Z.   +5 more
europepmc   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source

Predictive Coding Light. [PDF]

Nat Commun
N'dri AW, Barbier T, Teulière C, Triesch J.   +3 more
europepmc   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

Aviadenovirus structure: A highly thermostable capsid in the absence of stabilizing proteins. [PDF]

PLoS Pathog
Pérez-Illana M, Schachner A, Hernando-Pérez M, Condezo GN, Paradela A, Martínez M, Marabini R, Hess M, San Martín C.   +8 more
europepmc   +1 more source