Results 31 to 40 of about 4,511 (269)

Instability of supersonic compression ramp flow [PDF]

open access: yesPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2014
The instability of supersonic compression ramp flow is investigated. It is assumed that the Reynolds number is large and that the governing equations are the unsteady triple-deck equations. The mean flow is first calculated by solving the steady equations for various scaled ramp angles α , and the numerical results ...
Logue, R.P.   +2 more
openaire   +4 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Airfoil leading edge blowing to control bow shock waves

open access: yesScientific Reports, 2020
This manuscript presents a detailed characterization of active control of bow shock waves via leading edge injection, including subsonic coolant ejection and the appearance of Coanda effects.
Francisco Lozano, Guillermo Paniagua
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Influences of the compressibility on aerodynamic characteristics of profile under the transonic flow theory

open access: yesVietnam Journal of Mechanics, 2007
Transonic flows are complex problems. At certain Mach numbers, in gas flows there are local transitions from the subsonic into the supersonic and reciprocally, especially the discontinuity throughout shock waves.
Hoang Thi Bich Ngoc
doaj   +1 more source

Photoacoustic Spectroscopy in a Supersonic Flow

open access: yesThe Journal of Physical Chemistry A
Photoacoustic spectroscopy (PAS) is a sensitive broadband absorption technique relying on simple and inexpensive components. Despite this, PAS has never been applied in a cold supersonic environment. The reason for this is clear: how can one detect an acoustic signal under supersonic conditions?
Liu, Yanan   +4 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Comparative Flow Field Analysis of Boundary Layer Diverter Intake and Diverterless Supersonic Intake Configuration

open access: yesJournal of Applied Fluid Mechanics, 2018
In this paper comparative flow field analysis of two intake configuration i.e. Boundary Layer Diverter Intake and Diverterless Supersonic Intake is carried out based on dimensionless parameters under various flow conditions.
I. Arif   +4 more
doaj  

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