Results 131 to 140 of about 3,746,359 (297)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Interpretable weakly-supervised learning through kernel density matrices: A digital pathology use case.

PLoS ONE
Classification methods based on deep learning require selecting between fully-supervised or weakly-supervised approaches, each presenting limitations in uncertainty quantification and interpretability.
Sebastian Medina, Eduardo Romero, Angel Cruz-Roa, Fabio A González   +3 more
doaj   +1 more source

Semi-Supervised Classification of PolSAR Images Based on Co-Training of CNN and SVM with Limited Labeled Samples. [PDF]

Sensors (Basel), 2023
Zhao M, Cheng Y, Qin X, Yu W, Wang P.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Subclass-Aware Contrastive Semi-Supervised Learning for Inflammatory Bowel Disease Classification from Colonoscopy Images

Bioengineering
Inflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC). The accurate classification of IBD from colonoscopy images is critical for diagnosis and treatment.
Kechen Lin, Guangcong Ruan, Xiaoyang Zou, Yongjian Nian, Yanling Wei, Guoyan Zheng   +5 more
doaj   +1 more source

Semi-supervised Classification Based Mixed Sampling for Imbalanced Data

Open Physics, 2019
In practical application, there are a large amount of imbalanced data containing only a small number of labeled data. In order to improve the classification performance of this kind of problem, this paper proposes a semi-supervised learning algorithm ...
Zhao Jianhua, Liu Ning
doaj   +1 more source

Predicting HIV infection in the decade (2005-2015) pre-COVID-19 in Zimbabwe: A supervised classification-based machine learning approach. [PDF]

PLOS Digit Health, 2023
Birri Makota RB, Musenge E.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

EMD-Based Method for Supervised Classification of Parkinson's Disease Patients Using Balance Control Data. [PDF]

Bioengineering (Basel), 2022
Safi K, Aly WHF, AlAkkoumi M, Kanj H, Ghedira M, Hutin E.   +5 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source