Results 221 to 230 of about 242,529 (275)

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

The detection of algebraic auditory structures emerges with self-supervised learning. [PDF]

PLoS Comput Biol
Orhan P, Boubenec Y, King JR.
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Artificial Intelligence in Ocular Transcriptomics: Applications of Unsupervised and Supervised Learning. [PDF]

Cells
Lalman C, Yang Y, Walker JL.
europepmc   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Self-supervised learning with BYOL for anterior cruciate ligament tear detection from knee MRI. [PDF]

MethodsX
Aidarkhan A, Mukhamediya A, Askhatova A, Beisembekova R, Alimbayeva Z, Ozhikenova A, Ozhikenov K, Jamwal PK.   +7 more
europepmc   +1 more source

CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions

Advanced Science, EarlyView.
CellPolaris decodes how transcription factors guide cell fate by building gene regulatory networks from transcriptomic data using transfer learning. It generates tissue‐ and cell‐type‐specific networks, identifies master regulators in cell state transitions, and simulates TF perturbations in developmental processes.
Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, Yiyang Zhang, Wentao Cui, Yao Chen, Shirui Li, Wenhao Liu, Yao Tian, Yana Liu, Jingxi Dong, Ping Xu, Zhenpeng Man, Guole Liu, Zhongming Liang, Xinlong Jiang, Xiaodong Yang, Pengfei Wang, Ge Yang, Hongmei Wang, Xuezhi Wang, Ming‐Han Tong, Yuanchun Zhou, Shihua Zhang, Yiqiang Chen, Yong Wang, Xin Li   +27 more
wiley   +1 more source

DINO-EYE: self-supervised learning for identification of different optic disc phenotypes in primary open angle glaucoma. [PDF]

Sci Rep
Grassi L, Fei Z, Morales E, Caprioli J.
europepmc   +1 more source

A Degradable Bioinspired Flier with Aerogel‐Based Colorimetric Sensors for Environmental Monitoring

Advanced Science, EarlyView.
Biodegradable fliers are developed inspired by Tipuana tipu samaras, integrating cellulose nanocrystal aerogel (CNCa) sensors loaded with natural dyes for pH and ammonia detection. The lightweight, degradable fliers mimic natural morphology and aerodynamics, offering an eco‐friendly, scalable solution for in situ environmental monitoring after passive ...
Gianpaolo Gallo, Ruowen Tu, Carlo Filippeschi, Stefano Mariani, Barbara Mazzolai   +4 more
wiley   +1 more source

Domain-adaptive semi-supervised learning for efficient rare pathological lesion detection with minimal annotation. [PDF]

NPJ Digit Med
Matsui I, Matsumoto A, Imai A, Okushima H, Niioka H, Abe M, Tamai N, Nagasu H, Kanda E, Uchino E, Sofue T, Imasawa T, Yano Y, Kinashi H, Miyoshi KI, Harada T, Nagasawa Y, Fujimoto K, Kurokawa Y, Kato S, Kaseda R, Koizumi M, Kusunoki Y, Ohya M, Kawazoe Y, Abe H, Matsukuma Y, Kosugi T, Ueda Y, Fujii N, Takeji M, Suzuki A, Nagatoya K, Oka K, Ando Y, Izumi M, Komiya T, Tsukamoto T, Mimura I, Kuragano T, Nakano T, Tsuruya K, Ito Y, Minamino T, Yamaguchi O, Yamamoto S, Komaba H, Furuichi K, Fukami K, Araki SI, Masaki T, Tsuboi N, Yokoyama H, Shimizu A, Ushiku T, Maruyama S, Yanagita M, Nangaku M, Yamamoto R, Inoue K, Isaka Y.   +60 more
europepmc   +1 more source