Results 181 to 190 of about 2,396,272 (238)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Comparative effectiveness of anti-CD20 therapies and S1P receptor modulators in late-onset multiple sclerosis: real-world evidence from the MSBase registry. [PDF]

Ther Adv Neurol Disord
Surcinelli A, Kalincik T, Roos I, D'Amico E, Lechner-Scott J, Ozakbas S, Hradilek P, Horáková D, Vachova M, Panzera I, Ruzza S, Piscaglia MG, Gerlach O, Meca-Lallana JE, Valero-López G, Kermode AG, Fabis-Pedrini MJ, Prevost J, Ampapa R, Hodgkinson S, Grand'Maison F, Khoury SJ, John NA, Peterka M, Houskova J, Recmanova E, Rous Z, Shaygannejad V, Alroughani R, Kuhle J, Jakob GB, Grammond P, Patti F, Van der Walt A, Butzkueven H, Foschi M.   +35 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Weiterführung der Theoriereihe Reflexive Supervision

Forum Supervision
Forum Supervision
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Peer Mentor Training and Supervision for a Digital Adolescent Depression Treatment in South Africa and Uganda: Mixed Methods Evaluation.

JMIR Ment Health
Makhanya Z, Moffett B, Pozuelo JR, Davis M, Gumikiriza-Onoria JL, Geffen S, Baloyi T, Sodi T, Kinyanda E, Craske MG, Tusiime C, Lund C, Van Heerden A, Kahn K, Stein A, O'Mahen H, DoBAt and Ebikolwa Consortium.   +16 more
europepmc   +1 more source

The Impact of Abusive Supervision on Quiet Quitting: The Mediating Role of Sleep Deprivation and the Moderating Role of Proactive Personality. [PDF]

Behav Sci (Basel)
Gong Z, Li X, Choi H, Kang SW.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source