Results 71 to 80 of about 2,351,817 (237)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
La supervisión en los equipos de Servicios Sociales: una oportunidad para la reflexión, el pensamiento y el cuidado de los profesionales [PDF]
, 2011 The supervision and evaluation of professionals within Social Services teams in today’s context becomes an opportunity for reflection, thought and care. The practice of supervision in organizations operating within a complex society must be directed from
Puig i Cruells, Carmina
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
La supervisión educativa en Trabajo Social: un estudio comparado entre distintas universidades [PDF]
, 2014 Este texto muestra una aproximación a la Supervisión educativa, a cómo se está estructurando esta materia en el grado de Trabajo Social y a cuáles son los contenidos y metodologías que se están implementando en diferentes universidades de cara a poder ...
Ariño Altuna, Miren +2 more
core
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
La estabilidad financiera en la Unión Europea y la supervisión prudencial de las entidades de crédito [PDF]
, 2014 La intensidad de la crisis económica y financiera ha comportado la necesidad de crear instrumentos de asistencia financiera para rescatar a países con déficit fiscal incapaces de financiarse de manera autónoma.
Olesti Rayo, Andreu
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Nuevas tecnologías e inclusión en el ámbito de la Educación Social [PDF]
, 2012 Todo el material que se recopila a continuación está elaborado por los alumnos de la asignatura “Recursos Tecnológicas para la Atención Educativa a la Diversidad” del curso académico 2012-2013 bajo la supervisión del profesor de la asignatura, Vicente
Gabarda Méndez, Vicente
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source