Results 71 to 80 of about 2,063,309 (209)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Spatial Distribution of Cadmium in Avocado-Cultivated Soils of Peru: Influence of Parent Material, Exchangeable Cations, and Trace Elements

Agriculture
Potentially toxic elements such as cadmium (Cd) in agricultural soils represent a global concern due to their toxicity and potential accumulation in the food chain.
Richard Solórzano, Rigel Llerena, Sharon Mejía, Juancarlos Cruz, Kenyi Quispe   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Spatial Variability of Soil Acidity and Lime Requirements for Potato Cultivation in the Huánuco Highlands

Agriculture
Soil acidity is a major limiting factor for potato production in Peru’s high Andean region. This study aims to predict the spatial variability of soil acidity as a fundamental tool for recommending site-specific liming treatments and to identify the ...
Kenyi Quispe, Sharon Mejía, Carlos Carbajal, Lidiana Alejandro, Patricia Verástegui, Richard Solórzano   +5 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Supervisión de las acciones esenciales de seguridad del paciente en las unidades médicas en una institución de salud

Cirugía y Cirujanos
Objetivo: Determinar la importancia de la supervisión de las acciones esenciales de seguridad del paciente (AESP) en las diferentes unidades médicas de los distintos niveles de atención en la Ciudad de México. Método: La preocupación por la calidad en la
Miguel A. Serrani-Berrones, Sergio B. Barragán-Padilla, María T. García-Avelino   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Estudio de caso: Supervisión técnica de obras en proyectos de reforzamientos estructural de edificaciones verticales basado en la experiencia en la obra LJCG

, 2023
Algunas obras de edificaciones verticales requieren contar con supervisión técnica, considerando el nivel de importancia y tamaño de la estructura. La supervisión técnica de obra es una tarea que realizan profesionales de ingeniería civil. Conocer cómo
Zuluaga Zuluaga, Kely Andrea
core  

The impact of microbial colonization on cadmium adsorption by rice husk biochar: microorganism-dependent outcomes in bioretention systems

Frontiers in Microbiology
IntroductionThe use of microorganisms and biochar, individually, has been proposed as a promising strategy for the bioremediation of heavy metals in contaminated water bodies.
Carlos Curi-Zavala, Michell K. Arroyo-Julca, Ricardo Flores-Marquez, Emilee Calero-Rios, Sady García, Richard Solórzano-Acosta   +5 more
doaj   +1 more source