Results 71 to 80 of about 2,396,272 (238)
Germany and Spain lead changes towards international insolvencies in Europe [PDF]
, 2003 With the Council regulation (EC) No. 1346/2000 of 29 May 2000 on insolvency proceedings, that came into effect May 31, 2002 the European Union has introduced a legal framework for dealing with cross-border insolvency proceedings.
Wessels, Bob
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Desarrollo de un manual para la supervisión a contratos de interventoría de obras en la policía nacional de Colombia [PDF]
, 2017 Trabajo de investigaciónLa estructura actual con la que cuenta la Policía Nacional, en el proceso de la supervisión de contratos de interventoría para obra, limita la eficacia a la gestión desarrollada por profesionales que cumplen estas funciones de ...
Jiménez-Gil, Camilo +2 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
La supervisión educativa en nuestro país: El trabajo del supervisor en cinco jurisdicciones [PDF]
, 2013 En las últimas décadas, en la mayoría de los países se han implementado políticas que resignifican el trabajo del supervisor poniendo un mayor énfasis en las tareas relacionadas con el apoyo, el asesoramiento, y el acompañamiento a las escuelas y los ...
Actis, Karina (diseño) +12 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Veterinary SciencesCreole goats have adapted to the harsh Andean environment, yet the physiological impacts of high-altitude production systems remain underexplored. This study assessed seasonal and dietary influences on the hematological and biochemical profiles of 45 ...
Aníbal Rodríguez-Vargas +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source