Can bank supervisors rely on market data? A critical assessment from a Swiss perspective [PDF]
Market data, such as bond spreads or equity price volatility, are a complementary source to bank supervisory information. In Switzerland, meaningful market data are available for a number of banks which constitute a major part of the banking system ...
Matteo Facchinetti, Urs W. Birchler
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Institutional structures of financial sector supervision, their drivers and emerging benchmark models [PDF]
This paper studies the development of institutional structures for prudential and business conduct supervision of financial services over the past decade for 98 high and middle income countries.
Melecky, Martin, Podpiera, Anca Maria
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Can the stock market tell bank supervisors anything they don't already know? [PDF]
This article provides evidence consistent with recent policy proposals calling for a greater role for market forces in promoting a safe and sound financial system.
Jeffery W. Gunther +2 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Supervising the unseen: A critical literature review on supervising students with hidden disabilities in South Africa. [PDF]
Afr J DisabilRielander CL.
europepmc +1 more source
A Squandered Opportunity: Even after the Financial Crisis, Top Positions in Large Financial Firms Still Largely Occupied by Men [PDF]
Despite the recent financial crisis and widespread mergers in the banking industry, the German financial sector remains largely unchanged in one respect: the percentage of women on the corporate boards of Germany's banks and insurance companies was ...
Elke Holst, Julia Schimeta
core