Results 31 to 40 of about 268,529 (266)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Survey On Competence and Administration of Supervisory Board Activities in German Stock-Listed Companies

Economics and Business, 2017
According to the agency theory (Jensen & Meckling 1976), it is expected that there exists a positive relationship between corporate governance and company performance which is also generally assumed in recent research (Dignam & Galanis 2016).
Michelberger Knut J.
doaj   +1 more source

Classical and modern concepts of corporate governance (Stewardship Theory and Agency Theory)

Management, 2015
The main issues in efficiency of a company as an organisation are relations between the Supervisory Board and the Management Board of a company, and the methods of functioning of Supervisory Boards in governance systems of a company.
Glinkowska Beata, Kaczmarek Bogusław
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Recent developments in German corporate governance. [PDF]

, 2008
This paper provides an overview of the German corporate governance system. We review the governance role of large shareholders, creditors, the product market and the supervisory board.
Admati, Agarwal, Aghion, Aghion, Allen, Barca, Barclay, Barclay, Barclay, Bebchuk, Bebchuk, Becht, Becht, Becht, Beck, Beck, Beinert, Berglöf, Berkovitch, Berle, Boehmer, Bolton, Burkart, Cable, Coffee, Conyon, Conyon, Conyon, Cubbin, Davis, Deeg, Demsetz, Denis, Dyck, Dyck, Edwards, Edwards, Elston, Elston, Faccio, Franks, Franks, Franks, Franks, Gedajlovic, Gehrig, Goergen, Goergen, Goergen, Goergen, Goergen, Goergen, Gorton, Grossman, Grossman, Grossman, Gugler, Gugler, Gugler, Hackethal, Harris, Hau, Hermalin, Himmelberg, Holderness, Holmstrom, Holmstrom, Januszewski, Jenkinson, Jenkinson, Jensen, Jirjahn, Johnson, Kaplan, Kaplan, Kaplan, Karpoff, Klette, Kole, Kraft, Köke, Köke, Köke, Köke, La Porta, La Porta, La Porta, Lehmann, Lehmann, Levine, Luc Renneboog, Manjon, Marc Goergen, Martynova, Miguel C. Manjon, Morck, Murphy, Nenova, Nickell, Nickell, Nickell, Noack, O'Sullivan, Pagano, Porter, Prigge, Renneboog, Roe, Ryngaert, Scharfstein, Schmid, Shleifer, Shleifer, Short, Terberger, Thonet, Tirole, Tirole, Tuschke, Van der Elst, Vitols, Vitols, von Werder, von Werder, von Werder, von Werder, von Werder, Walter, Weigand, Wöjcik, Zingales, Zwiebel   +131 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Pengaruh Penerapan Peran Komite Audit, Peran Dewan Pengawas Syariah, dan Efektivitas Pengendalian Intern Atas Pelaporan Keuangan terhadap Kualitas Pelaporan Keuangan (Studi Empiris pada Bank Syariah di Indonesia) [PDF]

, 2014
This study examines the effect of audit committee role, shari’a supervisory board role, and internal control over financial reporting effectiveness, on financial reporting quality. The data is taken by questionnaire from 173 employees (group head ...
Rini, R. (Rini)
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

When do regulations matter for bank risk-taking? An analysis of the interaction between external regulation and board characteristics [PDF]

, 2018
PurposeAccording to previous international studies, the impact of external regulation on bank risk is ambiguous. The purpose of this paper is to ask the question, “When do regulations matter for bank risk-taking?” by reporting the first empirical ...
De Vita, Glauco, Luo, Yun
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source