Results 71 to 80 of about 268,529 (266)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Subprime Crisis and Board (In-)Competence: Private vs. Public Banks in Germany [PDF]

open access: yes
We examine evidence for a systematic underperformance of Germany’s state-owned banks in the current financial crisis and study if the bank losses can be traced to the quality of bank governance. For this purpose, we examine the biographical background of
Harald Hau, Marcel Thum
core  

Dewan Pengawas Syariah dan Pengungkapan Aspek Lingkungan, Produk dan Jasa pada Bank Syariah [PDF]

open access: yes, 2016
This study aims to provide empirical evidence of the influence of the role of the Sharia Supervisory Board on the disclosure of environmental aspects and aspects of banking services product on Islamic banking in Indonesia based on Islamic Social ...
Purwanti, A. (Ari)
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Dewan Pengawas Syariah dan Pengungkapan Sukarela Pada Bank Umum Syariah di Indonesia

open access: yesJurnal Riset Akuntansi dan Keuangan, 2018
. This study aims to determine the influence of shariah dupervisory board on the voluntary disclosure in shariah commercial bank in Indonesia during 2013 to 2016.
Elis Mediawati, Indria Fitri Afiyana
doaj   +1 more source

Women Still Greatly Underrepresented on the Top Boards of Large Companies [PDF]

open access: yes
Executive and supervisory boards of large companies in Germany are still dominated by men - to an extraordinary degree. Only 2.5% of all executive board members in the200 largest companies (not including the financial sector) are women, and only 10% of ...
Anita Wiemer, Elke Holst
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Tanggung Jawab Majelis Pengawas Daerah Terhadap Penyerahan Penyimpanan Protokol Notaris yang Berumur Lebih Dari 25 Tahun

open access: yesJurnal Ilmu Kenotariatan
The issue at hand is the storage of Notary Protocol documents that are 25 years or older, which are still held by the receiving notary. The transfer of Notary Protocol documents aged 25 years or older from the receiving notary to the Regional Supervisory
Nandita Mentari Nasution   +1 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

The Nexus Between Board Diversity and Sustainability Reporting: The Moderating Role of Supervisory Effectiveness and Quality in a Two-Tier Board System

open access: yesSAGE Open
This study aimed to investigate how Board of Director (BOD) diversity affected sustainability reporting in Islamic banks in Indonesia. The effectiveness of three supervisory bodies, namely the Board of Commissioners (BOC), the Audit Committee (AC), and ...
Rita Wijayanti, Doddy Setiawan
doaj   +1 more source

Home - About - Disclaimer - Privacy