Results 31 to 40 of about 86,179 (225)

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Orthostatic hypotension in older people: considerations, diagnosis and management. [PDF]

, 2021
Orthostatic hypotension (OH) is very common in older people and is encountered daily in emergency departments and medical admissions units. It is associated with a higher risk of falls, fractures, dementia and death, so prompt recognition and treatment ...
Dani, Melanie, Torocastro, Miriam, Lim, Phang Boon, Taraborrelli, Patricia, Panagopolous, Dimitrios, Sutton, Richard, Dirksen, Andreas   +6 more
core   +1 more source

Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors [PDF]

, 1994
To define some of the mechanisms underlying dextran sulfate (DXS)-induced hypotension, we investigated the effects of either the plasma kallikrein inhibitor des-Pro2-[Arg15] aprotinin (BAY x 4620) or the specific bradykinin B2-receptor antagonist Hoe-140
Siebeck, Matthias, Kohl, Jacek, Cheronis, John C., Spannagl, Michael, Jochum, Marianne, Spies, Bernd, Fritz, Hans, Fink, Edwin   +7 more
core   +2 more sources

Sit-up test for assessing impaired blood pressure regulation in community-dwelling older adults: a cross-sectional study

BMC Geriatrics
Background The sit-up test enables safe orthostatic hypotension assessment without using a tilt table in high fall-risk individuals; however, no study has compared blood pressure responses between older adults with and without orthostatic hypotension ...
Kazuaki Oyake, Yoshiharu Yokokawa
doaj   +1 more source

Trendelenburg positioning with or without norepinephrine infusion for haemodynamic support in anaesthetised hypovolemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Intraoperative haemorrhage during equine anaesthesia is a rare but potentially fatal complication requiring prompt haemodynamic support. Postural manoeuvres such as Trendelenburg (TL) positioning and vasopressor support augment venous return and improve cardiac output (CO), yet their efficacy in anaesthetised hypovolemic horses ...
Vaidehi V. Paranjape, Klaus Hopster, Ismar Lutvikadic, Bernd Driessen   +3 more
wiley   +1 more source

Cerebral microbleeds and blood pressure abnormalities in Parkinson's disease

eNeurologicalSci, 2018
Blood pressure abnormalities are frequently observed in patients with Parkinson's disease (PD), and are associated with cerebrovascular diseases such as white matter hyperintensities and carotid atherosclerosis. We assessed the relationship between blood
Kazuo Yamashiro, Ryota Tanaka, Yasushi Shimo, Genko Oyama, Takashi Ogawa, Atsushi Umemura, Nobutaka Hattori   +6 more
doaj   +1 more source

Incidental Detection of Portal Venous Gas During POCUS in a Neonate With Necrotizing Enterocolitis and Intestinal Perforation: A Case Report

Journal of Clinical Ultrasound, EarlyView.
Point‐of‐care ultrasound performed at the bedside identified hepatic portal venous gas in a critically ill neonate, prompting urgent evaluation and revealing intestinal perforation due to necrotizing enterocolitis. This case highlights the potential of POCUS to accelerate diagnosis when clinical signs are subtle or nonspecific.
Tiago Henrique de Souza, Elisa Caixeta Fallieri Nascimento, Fernando de Lima Carioca, Nayara Hillebrand Franzon, Humberto Magalhães Silva   +4 more
wiley   +1 more source

Ipotensione ortostatica e ipertensione supina: guida pratica a diagnosi e terapia=Orthostatic hypotension and supine hypertension: a practical guide to diagnosis and management

, 2021
Orthostatic hypotension is a medical condition potentially debilitating and associated with a negative prognosis. It is paramount for cardiologists to recognize it, mostly for the following reasons: it is a predictive factor for cardiovascular events, it
Borghi C., Pensato U, Cortelli P, Strocchi E   +3 more
core   +1 more source

Transcutaneous Spinal Cord Stimulation Attenuates Blood Pressure Drops in Orthostasis

Life, 2022
Orthostatic hypotension is a complex medical problem with various underlying pathogenic mechanisms and limited modalities for its correction. Since transcutaneous spinal cord stimulation (t-SCS) leads to immediate blood pressure (BP) elevation in a ...
Natalia N. Beliaeva, Tatiana R. Moshonkina, Oleg V. Mamontov, Elena N. Zharova, Heber Ivan Condori Leandro, Nigar Z. Gasimova, Evgeny N. Mikhaylov   +6 more
doaj   +1 more source

Capsulotomy With Supine Nd:YAG Laser in Children

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives To evaluate the visual outcomes of Nd:YAG laser posterior capsulotomy performed in the supine position under general anesthesia in children with visual axis opacification after cataract surgery. Materials and Methods A retrospective clinical case series of 13 eyes of 9 children with visual axis opacification following congenital ...
Nike Klun, Manca Tekavčič Pompe
wiley   +1 more source