Results 131 to 140 of about 4,159,619 (382)

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Cross-over study of novice intubators performing endotracheal intubation in an upright versus supine position [PDF]

, 2016
There are a number of potential physical advantages to performing orotracheal intubation in an upright position. The objective of this study was to measure the success of intubation of a simulated patient in an upright versus supine position by novice ...
Cooper, Dylan D., Eddy, Christopher S., Ellender, Timothy J., Okonkwo, Enola R., Perkins, Anthony J., Sembroski, Erik G., Stepsis, Tyler M., Stevens, Andrew C., Turner, Joseph S.   +8 more
core   +1 more source

Spirometric Values in Sitting, Standing and Supine Position

, 2015
Background: Spirometry may be done either in sitting or standing position. The effect of sitting, standing and supine position on ventilatory functions has not been well studied in healthy subjects. Objective: The objectives of this study were to compare
Anand K. Patel, Helee M. Thakar
semanticscholar   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Magic angle effect in MR imaging of ankle tendons: influence of foot positioning on prevalence and site in asymptomatic subjects and cadaveric tendons [PDF]

, 2018
The influence of foot positioning on prevalence of the magic angle effect (MAE) in ankle tendons was investigated. In 30 asymptomatic volunteers and five cadaveric feet, MR imaging of the ankle was performed in the supine (neutral position of the foot ...
Bode, Beata, Hodler, Juerg, Mengiardi, Bernard, Pfirrmann, Christian, Schöttle, Philip, Vienne, Patrick, Zanetti, Marco   +6 more
core  

Early Detection of Chemotherapy‐Induced Glucose Metabolic Alterations in Bladder Carcinoma Using Deuterium (2H) Metabolic Imaging: in Vitro and in Vivo Assessments

Advanced Science, EarlyView.
This study presents the first application of deuterium metabolic imaging (DMI) for assessing therapeutic response in bladder cancer. Employing [2,3,4,6,6′‐2H5]‐D‐glucose, DMI successfully identified chemotherapy‐induced suppression of glycolysis both in vitro and in vivo.
Lingmin Kong, Ganghan Yang, Bei Weng, Zhihua Wen, Joshua D. Kaggie, Qian Cai, Qian Wan, Cuien Zheng, Feng Du, Ye Li, Xin Liu, Ferdia A. Gallagher, Yan Guo, Shi‐Ting Feng, Chao Zou, Huanjun Wang   +15 more
wiley   +1 more source

Effects of orthostatic hypotension on cognition in Parkinson's disease [PDF]

, 2017
OBJECTIVE: To investigate the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in Parkinson disease (PD) using a cross-sectional and within-group design.
Canova, Alex O., Centi, Justin, Cronin-Golomb, Alice, Freeman, Roy, Gibbons, Christopher H., Neargarder, Sandy   +5 more
core  

Pre- and Post-alpha Motoneuronal Control of the Soleus H-reflex during Sinusoidal Hip Movements in Human Spinal Cord Injury [PDF]

, 2006
The aim of this study was to establish the contribution of hip-mediated sensory feedback to spinal interneuronal circuits during dynamic conditions in people with incomplete spinal cord injury (SCI).
Chaudhuri, Debjani, Kay, Elizabeth, Knikou, Maria, Schmit, Brian D.   +3 more
core   +2 more sources

The Effect of the Supine Position on Renal Function in the Near-Term Pregnant Woman12 [PDF]

, 1955
Jack A. Pritchard, Allan C. Barnes, Richard H. Bright   +2 more
openalex   +1 more source

Injectable Chondroitin Sulfate Methacrylate Hydrogel Microspheres Co‐Loaded with GLPM Nanozyme, Dexamethasone, and Stem Cells for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
A multifunctional injectable microsphere system is fabricated via UV‐assisted microfluidic cross‐linking, integrating nanozyme‐based ROS scavenging, sustained dexamethasone release, and stem cell delivery. Upon IA injection, the microspheres adapt to joint stress, suppress inflammation, and promote cartilage regeneration, offering a minimally invasive ...
Xiaochen Feng, Ying Fang, Hongwei Yu, Yicheng Wang, Yunze Xu, Chunxiao Shi, Haike Xia, Ranjith Kumar Kankala, Aizheng Chen, Shibin Wang, Chaoping Fu   +10 more
wiley   +1 more source