Results 181 to 190 of about 264,801 (332)

Concentration–QTc Modeling to Support Clinical Development of Fezolinetant

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin‐3 receptor antagonist that blocks neurokinin B activation of kisspeptin/neurokinin B/dynorphin neurons to thereby modulate neuronal activity in the thermoregulatory center. Fezolinetant has been approved in many regions, including North America, Europe, Asia, and Australia for the treatment ...
Jace C. Nielsen, Masako Saito, Xuegong Wang, Megumi Iwai, Graeme L. Fraser, Steven Ramael, Jiayin Huang   +6 more
wiley   +1 more source

Metabolic changes during cardiac regeneration in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich, Sofie Amalie Andersson, Morten Busk, Kasper Hansen, Casper Bindzus Foldager, Johan Palmfeldt, Asger Andersen, Michael Pedersen, Mikkel Vendelbo, Kirstine Lykke Nielsen, Henrik Lauridsen   +10 more
wiley   +1 more source

A Simple and Novel Modification of the Nebulization Mask to Improve Nebulization in the Supine Position. [PDF]

Turk J Anaesthesiol Reanim, 2023
Kaushal A, Kumar H, Waindeskar V, Sharma JP.   +3 more
europepmc   +1 more source

Reduced dose to small bowel with the prone position and a belly board versus the supine position in neoadjuvant 3D conformal radiotherapy for rectal adenocarcinoma [PDF]

, 2016
Rohen White, Farshad Foroudi, Joseph Sia, Mary Ann Marr, Daryl Lim Joon   +4 more
openalex   +1 more source

Multivariate linear regression to predict association of non‐invasive arterial stiffness with cardiovascular events

ESC Heart Failure, Volume 12, Issue 2, Page 1141-1150, April 2025.
Abstract Background Arterial stiffness is a crucial factor in determining an increase in systolic blood pressure and pulse pressure and can also predict the development of cardiovascular disease (CVD). The purpose of this study was to examine the relationship between arterial stiffness and future CVD.
Susan Darroudi, Mostafa Eslamiyeh, Amin Mansoori, Eisa Nazar, Maryam Alinezhad‐Namaghi, Reza Rezvani, Majid Ghayour‐Mobarhan, Habibollah Esmaily, Mohsen Moohebati, Gordon A. Ferns, Mark Ghamsary   +10 more
wiley   +1 more source

Exercise‐induced out‐of‐proportion increase in afterload and impaired right ventricular contractile reserve in HFpEF

ESC Heart Failure, EarlyView.
Non‐cardiac dyspnoea (n = 34, NCD) and heart failure with preserved ejection fraction (n = 34, HFpEF) patients were classified according to right heart catheterisation. Cardiovascular magnetic resonance derived right ventricular (RV) haemodynamic indices for afterload (Ea), contractility (Ees) and RV/pulmonary artery coupling (Ea/Ees) were evaluated ...
Jan Sebastian Wolter, Alexander Schulz, Torben Lange, Steffen D. Kriechbaum, Shelby Kutty, Johannes T. Kowallick, Julia M. Treiber, Andreas Rolf, Samuel Sossalla, Gerd Hasenfuß, Andreas Schuster, Sören J. Backhaus   +11 more
wiley   +1 more source

Single-position intraperitoneal laparoscopic radical nephroureterectomy using a modified supine position. [PDF]

BMC Urol
Han X, Zhou M, Xiong M, Xiao Y, Wu Y, Jiang H, Tu M, Wu S, Hou T.   +8 more
europepmc   +1 more source

Supine-Position Ultrasound-Assisted Arthroscopic Surgery for Elbow Joint Contracture: A Case Report. [PDF]

Cureus, 2023
Omodani T.
europepmc   +1 more source

Physical and Psychological Effects of Head Treatment in the Supine Position Using Specialized Ayurveda-Based Techniques [PDF]

, 2016
Masako Murota, Yoko Iwawaki, Kazuo UEBABA, Yōko Yamamoto, Yukie Takishita, Kiyomi Harada, Akemi Shibata, Jin Narumoto, Kenji Fukui   +8 more
openalex   +1 more source

Effects of geranylgeranylacetone on diastolic and microvascular function in patients with heart failure with a preserved ejection fraction: A phase 2, randomized, placebo‐controlled, crossover trial

European Journal of Heart Failure, EarlyView.
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a major healthcare burden with limited treatment options. Geranylgeranylacetone (GGA) has been shown to improve myocardial compliance and endothelial function in preclinical models.
Soufiane Nassiri, Geert H.D. Voordes, Loek van Heerebeek, Daniël H. van Raalte, Marianne C. Verhaar, Daan J. Touw, Merle M. Krebber, Dirk J. Duncker, Etto C. Eringa, M. Louis Handoko, Adriaan A. Voors, on behalf of the RECONNEXT Consortium   +11 more
wiley   +1 more source