Results 41 to 50 of about 3,889 (259)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Porcelain Polishing Residue as a Supplementary Cementitious Material in Self-Compacting Concrete: Pozzolanic Activity and Performance Assessment

Powders
The increasing demand for sustainable construction materials has intensified research on supplementary cementitious materials capable of reducing Portland cement consumption and associated CO2 emissions. In this context, porcelain polishing residue (PPR),
Alexandre Serafim, Elaine Antunes, Gláucia Dalfré, Ricardo de Almeida   +3 more
doaj   +1 more source

Behavior of self- compacting concrete incorporating calcined pyrophyllite as supplementary cementitious material

Journal of Building Materials and Structures, 2020
The current trend of industrial concrete leans more towards the use of self-compacting concrete. These must have fresh properties well defined as fluidity, filling ability and resistance to segregation.
Sabria Malika Mansour
doaj   +1 more source

Characteristics of Kedondong Trass and Bobos Trass as Cement Raw Material, Cirebon, West Java, Indonesia

JGEET: Journal of Geoscience, Engineering, Environment and Technology, 2022
The use of cement materials in construction continues to increase every year, consumes lots of raw material and emits CO2 from clinker production. To eliminate this negative effect, alternative materials are needed.
Jenian Marin, Tri Winarno, Shofiana Nadia Fairuz   +2 more
doaj   +1 more source

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond

Advanced Science, EarlyView.
Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu, Gewei Yan, Zhentao She, Yingzhu He, Kangqi Liu, Jianan Qu   +5 more
wiley   +1 more source

Production of supplementary cementitious material as a sustainable management strategy for water treatment sludge waste

Case Studies in Construction Materials, 2020
This paper investigates the application of Water Treatment Sludge (WTS), the main waste generated by water potabilization activities, for the development of a Supplementary Cementitious Material (SCM).
Luis Gabriel Graupner de Godoy, Abrahão Bernardo Rohden, Mônica Regina Garcez, Silvana Da Dalt, Lucas Bonan Gomes   +4 more
doaj   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Lime-activation of natural pozzolan for use as supplementary cementitious material in concrete

Ain Shams Engineering Journal, 2022
The present work was conducted to examine the beneficial effects of activating natural pozzolan (NP) using hydrated lime (HL) for its efficient utilization in concrete.
Omar S. Baghabra Al-Amoudi, Shamsad Ahmad, Mohammed Maslehuddin, Saad M.S. Khan   +3 more
doaj   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Composition of Engineered Cementitious Composite with Local Materials, Composite Properties and Its Utilization for Structures in Developing Countries

Engineering Proceedings, 2023
This study focuses on developing cost-efficient engineered cementitious composites (ECCs) with glass and polypropylene fibers, using local materials for sustainable construction in developing countries.
Amaan Sikandar, Majid Ali
doaj   +1 more source