Results 131 to 140 of about 37,401 (312)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Supplier Performance Evaluation And Supplier Reduction In Supply Chain Management
, 2015 Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2006Thesis (M.Sc.) -- İstanbul Technical University, Institute of Science and Technology, 2006Bu çalışmada, tedarikçi perfomansı değerlendirme süreçleri ve tedarikçi sayısı ...
Murat, Yusuf Serkan
core
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
This paper examines how firms succeed to leverage supplier involvement in product development. The paper extends earlier work on managing supplier involvement by providing an integrated analysis of results, processes and conditions both at the level of ...
Wynstra, J.Y.F. +2 more
core
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Supplier evaluation at Group Deutsche Börse
, 2008 This case study focuses on a key aspect of supply management: supplier evaluation. The case is set at Group Deutsche Borse (GDB) and describes how GDB changed its sourcing strategy for external services between 2000 and 2006.
Alsteens, S., Muylle, Steve
core
Supplier Evaluation and Selection Process [PDF]
, 2016 The subject of this thesis was the creation of a common supplier evaluation and selection process for Vaisala’s sourcing department. The goal was to analyze the current situation and to develop a global Vaisala supplier selection and evaluation process ...
Lammi, Hannele
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Supplier Evaluation Anatomized
, 1991 This paper presents an alternative approach to analyzing supplier evaluation. It is built on the traditional approaches in the sense that it acknowledges the influence of processes, interaction, networks and the business environment on supplier evaluation but goes on to conclude that the evaluation itself is still in most cases performed by a single ...
openaire +1 more source