Results 241 to 250 of about 37,401 (312)

A novel Z-number based multi-stage assessment framework for problem-based learning in practical courses. [PDF]

PLoS One
Yu L, Chen Z, Qin Z.
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Sustainable closed-loop supply chain network design under uncertainty using a fuzzy multi-objective optimization framework for the battery industry. [PDF]

Sci Rep
Attari MYN, Rezanejad S, Ala A, Simic V, Pamucar D.   +4 more
europepmc   +1 more source

Environmental evaluation in relationships with suppliers

, 2022
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Public procurement of cardiac implantable electronic devices across Europe: are we purchasing value or cost-effectiveness? [PDF]

Europace
Osoro L, Arbelo E, Kozhuharov N, Landen R, Martinek M, Leclerq C, Fauchier L, De Haro JC, Boveda S, Sommer P, Rienstra M, Symanski P, Farkowski M, Egorova A, Moscoso Costa F, Tint D, Simovic S, Dzhinsov K, Leyva F, Boriani G, Figueras J, Ihara Z, Merino JL, Burri H, Pürerfellner H, Casado-Arroyo R.   +25 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Limiting Onion Fly (<i>Delia antiqua</i>) and Onion Thrips (<i>Thrips tabaci</i>) Damage to Onions by Combined Use of Environmentally Acceptable Control Methods: Fact or Fantasy? [PDF]

Insects
Bohinc T, Trdan S.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Comparative assessment of species identification methods for European <i>Salicornia</i> sources: a multifaceted approach employing morphology, nuclear DNA content, phylogenetic markers, RNA topology, and SSR fingerprinting. [PDF]

Front Plant Sci
Fussy A, Austoni S, Winkelmann T, Papenbrock J.   +3 more
europepmc   +1 more source