Results 121 to 130 of about 2,387,410 (293)

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Innovation during the supplier selection process: A novel multi-stage process case

open access: yes, 2014
Established ideas on supplier selection have not moved much from the original premise of how to choose between bidders. Whilst we have added many different tools and refinements to choose between alternative suppliers, its nature has not evolved. We move
Pedraza, I.   +3 more
core   +1 more source

Effect of Risk Management Strategies on Supplier Selection at the Lower Benue River Basin Development Authority, Makurdi, Nigeria

open access: yes360
This study examined the impact of risk management strategies on supplier selection at the Lower Benue River Basin Development Authority (LBRBDA) in Makurdi. It was motivated by the growing importance of effective supplier selection in public procurement
Aondofa Tyozenda   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

It's fine for them, but what about us? Exploring the role of supplier management practices on public buyer satisfaction

open access: yesSocial Sciences and Humanities Open
Supplier management practices, such as supplier selection and evaluation, monitoring, and development, are multifaceted strategies aimed at enhancing supplier performance for the benefit of buyers.
Ismail Abdi Changalima
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

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